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A Mutation-Selection Model with Recombination for General Genotypes


About this Title

Steven N. Evans, Department of Statistics, 367 Evans Hall, University of California, Berkeley, California 94720-3860, David Steinsaltz, Department of Statistics, 1 South Parks Road, Oxford, OX1 3TG, United Kingdom and Kenneth W. Wachter, Department of Demography, 2232 Piedmont Avenue, University of California, Berkeley, CA 94720-2120

Publication: Memoirs of the American Mathematical Society
Publication Year 2012: Volume 222, Number 1044
ISBNs: 978-0-8218-7569-8 (print); 978-0-8218-9511-5 (online)
DOI: http://dx.doi.org/10.1090/S0065-9266-2012-00662-9
Published electronically: September 5, 2012
Keywords: Measure-valued, dynamical system, population genetics, quasi-linkage equilibrium, Poisson random measure, Wasserstein metric, Palm measure, shadowing, stability, attractivity
MSC (2010): Primary 60G57, 92D15; Secondary 37N25, 60G55, 92D10

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Table of Contents


Chapters

  • Chapter 1. Introduction
  • Chapter 2. Definition, existence, and uniqueness of the dynamical system
  • Chapter 3. Equilibria
  • Chapter 4. Mutation, selection, and recombination in discrete time
  • Chapter 5. Shattering and the formulation of the convergence result
  • Chapter 6. Convergence with complete Poissonization
  • Chapter 7. Supporting lemmas for the main convergence result
  • Chapter 8. Convergence of the discrete generation system
  • Appendix A. Results cited in the text

Abstract


We investigate a continuous time, probability measure-valued dynamical system that describes the process of mutation-selection balance in a context where the population is infinite, there may be infinitely many loci, and there are weak assumptions on selective costs. Our model arises when we incorporate very general recombination mechanisms into an earlier model of mutation and selection presented by Steinsaltz, Evans and Wachter in 2005 and take the relative strength of mutation and selection to be sufficiently small. The resulting dynamical system is a flow of measures on the space of loci. Each such measure is the intensity measure of a Poisson random measure on the space of loci: the points of a realization of the random measure record the set of loci at which the genotype of a uniformly chosen individual differs from a reference wild type due to an accumulation of ancestral mutations. Our motivation for working in such a general setting is to provide a basis for understanding mutation-driven changes in age-specific demographic schedules that arise from the complex interaction of many genes, and hence to develop a framework for understanding the evolution of aging.

We establish the existence and uniqueness of the dynamical system, provide conditions for the existence and stability of equilibrium states, and prove that our continuous-time dynamical system is the limit of a sequence of discrete-time infinite population mutation-selection-recombination models in the standard asymptotic regime where selection and mutation are weak relative to recombination and both scale at the same infinitesimal rate in the limit.

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