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Stability of pulse solutions for the discrete FitzHugh-Nagumo system
Authors:
H. J. Hupkes and B. Sandstede
Journal:
Trans. Amer. Math. Soc. 365 (2013), 251-301
MSC (2010):
Primary 34A33, 34K26, 34D35, 34K08
Posted:
July 11, 2012
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Abstract: We show that the fast travelling pulses of the discrete FitzHugh-Nagumo system in the weak-recovery regime are nonlinearly stable. The spectral conditions that need to be verified involve linear operators that are associated to functional differential equations of mixed type. Such equations are ill-posed and do not admit a semi-flow, which precludes the use of standard Evans-function techniques. Instead, we construct the potential eigenfunctions directly by using exponential dichotomies, Fredholm techniques and an infinite-dimensional version of the Exchange Lemma.
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- A. Carpio, Asymptotic Construction of Pulses in the Discrete Hodgkin-Huxley Model for Myelinated Nerves, Physical Review E 72 (2005), 011905. MR 2178366 (2006e:92008)
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- -, Wave Trains, Self-Oscillations and Synchronization in Discrete Media, Physica D 207 (2005), 117-136. MR 2166978 (2006d:37165)
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- J. W. Evans, Nerve Axon Equations, IV: The Stable and Unstable Impulse, Indiana Univ. Math. J. 24 (1975), 1169-1190. MR 0393891 (52:14698)
- [EVV05]
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- [GS07]
- A. Ghazaryan and B. Sandstede, Nonlinear Convective Instability of Turing-Unstable Fronts Near Onset: A Case Study, SIAM J. Appl. Dyn. Sys. 6 (2007), 319-347. MR 2318657 (2008d:37137)
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- D. Henry, Geometric Theory of Semilinear Parabolic Equations, Lecture Notes in Mathematics, vol. 840, Springer-Verlag, Berlin, 1981. MR 610244 (83j:35084)
- [HHK52]
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- [HS49]
- A. F. Huxley and R. Stampfli, Evidence for Saltatory Conduction in Peripheral Meylinated Nerve Fibres, J. Physiology 108 (1949), 315-339.
- [HS10]
- H. J. Hupkes and B. Sandstede, Travelling Pulse Solutions for the Discrete FitzHugh-Nagumo System, SIAM J. Appl. Dyn. Sys. 9 (2010), 827-882. MR 2665452
- [HVL93]
- J. K. Hale and S. M. Verduyn-Lunel, Introduction to Functional-Differential Equations, Springer-Verlag, New York, 1993. MR 1243878 (94m:34169)
- [HVL05]
- H. J. Hupkes and S. M. Verduyn-Lunel, Analysis of Newton's Method to Compute Travelling Waves in Discrete Media, J. Dyn. Diff. Eq. 17 (2005), 523-572. MR 2165558 (2006e:65129)
- [HVL07]
- -, Center Manifold Theory for Functional Differential Equations of Mixed Type, J. Dyn. Diff. Eq. 19 (2007), 497-560. MR 2333418 (2008c:34156)
- [HVL09]
- -, Lin's Method and Homoclinic Bifurcations for Functional Differential Equations of Mixed Type, Indiana Univ. Math. J. 58 (2009), 2433-2487. MR 2603755 (2011d:34147)
- [HZ93]
- D. Hankerson and B. Zinner, Wavefronts for a Cooperative Tridiagonal System of Differential Equations, J. Dyn. Diff. Eq. 5 (1993), 359-373. MR 1223452 (94c:34120)
- [JKL91]
- C. K. R. T. Jones, N. Kopell, and R. Langer, Construction of the FitzHugh-Nagumo Pulse Using Differential Forms, Patterns and Dynamics in Reactive Media (New York) (H. Swinney, G. Aris, and D. G. Aronson, eds.), IMA Volumes in Mathematics and its Applications, vol. 37, Springer, 1991, pp. 101-116. MR 1228919 (94e:92015)
- [Jon84]
- C. K. R. T. Jones, Stability of the Travelling Wave Solutions of the FitzHugh-Nagumo System, Trans. AMS 286 (1984), 431-469. MR 760971 (86b:35011)
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- J. P. Keener, Propagation and its Failure in Coupled Systems of Discrete Excitable Cells, SIAM J. Appl. Math. 47 (1987), 556-572. MR 889639 (88k:92028)
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- J. Keener and J. Sneyd, Mathematical Physiology, Springer-Verlag, New York, 1998. MR 1673204 (2000c:92010)
- [LE92]
- J. P. Laplante and T. Erneux, Propagation Failure in Arrays of Coupled Bistable Chemical Reactors, J. Phys. Chem. 96 (1992), 4931-4934.
- [Lil25]
- R. S. Lillie, Factors Affecting Transmission and Recovery in the Passive Iron Nerve Model, J. of General Physiology 7 (1925), 473-507.
- [MP99a]
- J. Mallet-Paret, The Fredholm Alternative for Functional Differential Equations of Mixed Type, J. Dyn. Diff. Eq. 11 (1999), 1-48. MR 1680463 (2000j:34107)
- [MP99b]
- J. Mallet-Paret, The Global Structure of Traveling Waves in Spatially Discrete Dynamical Systems, J. Dyn. Diff. Eq. 11 (1999), 49-128. MR 1680459 (2000k:37125)
- [MPVL]
- J. Mallet-Paret and S. M. Verduyn-Lunel, Exponential Dichotomies and Wiener-Hopf Factorizations for Mixed-Type Functional Differential Equations, J. Diff. Eq., to appear.
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- L. A. Ranvier, Lećons sur l'histologie du système nerveux, par m. l. ranvier, recueillies par m. ed. weber, F. Savy, Paris, 1878.
- [Rus89]
- A. Rustichini, Functional Differential Equations of Mixed Type: The Linear Autonomous Case, J. Dyn. Diff. Eq. 11 (1989), 121-143. MR 1010963 (91b:34108)
- [Ton03]
- A. Tonnelier, McKean Caricature of the FitzHugh-Nagumo Model: Traveling Pulses in a Discrete Diffusive Medium, Physical Review E 67 (2003), 036105. MR 1976825 (2004c:35228)
- [Yan85]
- E. Yanagida, Stability of Fast Travelling Wave Solutions of the FitzHugh-Nagumo Equations, J. Math. Biol. 22 (1985), 81-104. MR 802737 (87a:92019)
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- B. Zinner, Stability of Traveling Wavefronts for the Discrete Nagumo Equation, SIAM J. Math. Anal. 22 (1991), 1016-1020. MR 1112063 (92d:34146)
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Additional Information
H. J. Hupkes
Affiliation:
Division of Applied Mathematics, Brown University, 182 George Street, Providence, Rhode Island 02912
Address at time of publication:
Mathematisch Instituut, Universiteit Leiden, P.O. Box 9512, 2300 RA Leiden, The Netherlands
Email:
hjhupkes@dam.brown.edu, hhupkes@math.leidenuniv.nl
B. Sandstede
Affiliation:
Division of Applied Mathematics, Brown University, 182 George Street, Providence, Rhode Island 02912
Email:
bjorn{\textunderscore}sandstede@brown.edu
DOI:
http://dx.doi.org/10.1090/S0002-9947-2012-05567-X
PII:
S 0002-9947(2012)05567-X
Keywords:
Discrete FitzHugh–Nagumo system,
travelling pulses,
stability,
singular perturbation theory,
lattice differential equations,
functional differential equations.
Received by editor(s):
May 6, 2010
Received by editor(s) in revised form:
February 1, 2011
Posted:
July 11, 2012
Article copyright:
© Copyright 2012 American Mathematical Society
The copyright for this article reverts to public domain 28 years after publication.
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