Regular ArticleSynthetic Peptides Derived from the Fourth Domain of CD4 Antagonize CD4 Function and Inhibit T Cell Activation☆
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Abbreviations used: DIPEA, diisopropylethylamine; DMF, dimethylformamide; Fmoc, fluorenylmethoxy-carbonyl; HBTU, 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetra-methyluronium hexafluorophosphate; HOBt, 1-hydroxybenzotriazole; MALDI-TOF MS, matrix assisted laser desorption ionization time of flight mass spectrometry; MLR, mixed lymphocyte reaction; PyBOP, benzotriaole-1-yl-oxy-tris-pyrrolidimo-phosphonium hexafluorophosphate; RP-HPLC, reverse phase high performance liquid chromatography; TFA, trifluoroacetic acid.
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