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The Infinitely-Many-Alleles Model with Selection as a Measure-Valued Diffusion

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Stochastic Methods in Biology

Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 70))

Abstract

In [4], a diffusion model is constructed for a genetic system in which all alleles are selectively neutral and all mutants are new. The state of this model is the vector of order statistics of the gene frequencies. This reordering of the frequencies is necessary because of the assumption on mutation. Fixing the order of the alleles results in a model in which the sum of the gene frequencies is less than one for all positive time. Unfortunately, reordering makes it virtually impossible to study models with selection using this approach.

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References

  1. Dawson, D. A. (1978). Geostochastic calculus. Canad. J. Statist. 6, 143–168.

    MATH  Google Scholar 

  2. Dawson, D. A. and Hochberg, K. J. (1982). Wandering random measures in the Fleming-Viot model. Ann. Probab. 10, 554–580.

    Article  MathSciNet  MATH  Google Scholar 

  3. Ethier, S. N. and Griffiths, R. C. (1987). The infinitely-many-sites model as a measure-valued diffusion. Ann. Probab. 15, to appear.

    Google Scholar 

  4. Ethier, S. N. and Kurtz, T. G. (1981). The infinitely-many-neutral-alleles diffusion model. Adv. Appi. Probab. 13, 429–452.

    Article  MathSciNet  MATH  Google Scholar 

  5. Ethier, S. N. and Kurtz, T. G. (1986). Markov Processes: Characterization and Convergence. Wiley, New York.

    MATH  Google Scholar 

  6. Ethier, S. N. and Nagylaki, T. (1980). Diffusion approximations of Markov chains with two time scales and applications to population genetics. Adv. Appl. Probab. 12, 14–49.

    Article  MathSciNet  MATH  Google Scholar 

  7. Fleming, W. H. and Viot, M. (1979). Some measure-valued Markov processes in population genetics theory. Indiana Univ. Math. J. 28, 817–843.

    Article  MathSciNet  MATH  Google Scholar 

  8. Hochberg, K. J. (1986). Stochastic population theory: Mathematical evolution of a genetical model. In New Directions in Applied and Computational Mathematics. Springer-Verlag, to appear.

    Google Scholar 

  9. Kurtz, T. G. (1981). Approximation of Population Processes. CBMS-NSF Regional Conference Series in Applied Mathematics 36. SIAM, Philadelphia.

    Google Scholar 

  10. Li, W. H. (1978). Maintenance of genetic variability under the joint effects of mutation, selection, and random drift. Genetics 90, 349–382.

    MathSciNet  Google Scholar 

  11. Shiga, T., Shimizu, A., and Tanaka, H. (1986). Some measure-valued diffusion processes associated with genetical diffusion models, preprint.

    Google Scholar 

  12. Shimizu, A. (1985). Diffusion approximation of an infinite allele model incorporating gene conversion. In Population Genetics and Molecular Evolution. Ohta, T. and Aoki, K. eds. Springer-Verlag, Berlin, pp. 243–255.

    Google Scholar 

  13. Watterson, G. A. (1977). Heterosis or neutrality? Genetics 85, 789–814.

    MathSciNet  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Ethier, S.N., Kurtz, T.G. (1987). The Infinitely-Many-Alleles Model with Selection as a Measure-Valued Diffusion. In: Kimura, M., Kallianpur, G., Hida, T. (eds) Stochastic Methods in Biology. Lecture Notes in Biomathematics, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46599-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-46599-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17648-0

  • Online ISBN: 978-3-642-46599-4

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