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Mathematical Analysis of an HIV/AIDS Model: Impact of Educational Programs and Abstinence in Sub-Saharan Africa

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Journal of Mathematical Modelling and Algorithms

Abstract

We formulate a deterministic HIV/AIDS model to theoretically investigate how counselling and testing coupled with the resulting decrease in sexual activity could affect the HIV epidemic in resource-limited communities. The threshold quantities are determined and stabilities analyzed. Theoretical analysis and numerical simulations support the idea that increase in the number of sexually inactive HIV positive individuals who voluntarily abstain from sex has a positive impact on HIV/AIDS control. Results from this theoretical study suggest that effective counselling and testing have a great potential to partially control the epidemic (especially when HIV positive individuals either willingly withdraw from risky sexual activities or disclose their status beforehand) even in the absence of antiretroviral therapy (ART). Therefore, more needs to be done in resource-limited settings, such as sub-Saharan Africa, as far as the HIV/AIDS epidemic is concerned and a formalized information, education, and communication strategy should be given prominence in educational campaigns.

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References

  1. Birkhoff, G., Rota, G.C.: Ordinary Differential Equations. Ginn (1982)

  2. Bhunu, C.P., Garira, W., Magombedze, G.: Mathematical analysis of a two strain HIV/AIDS model with antiretroviral treatment. Acta Biotheor. 57, 361–381 (2009)

    Article  Google Scholar 

  3. Bhunu, C.P., Garira, W., Mukandavire, Z.: Modelling HIV/AIDS and tuberculosis co-infection. Bull. Math. Biol. 71, 1745–1780 (2009)

    Article  MATH  MathSciNet  Google Scholar 

  4. Bhunu, C.P., Garira, W.: A theoretical assessment of chemoprophylaxis, treatment and drug resistance in tuberculosis individuals co-infected with HIV/AIDS. In: Tchuenche, J.M., Chiyaka, C. (eds.) Infectious Disease Modelling Research Progress. Series: Public Health in the 21st Century, chapter 3, pp. 85–131. Nova Science Publishers (2009)

  5. Carr, J.: Applications of Centre Manifold Theory. Springer, New York (1981)

    MATH  Google Scholar 

  6. Castillo-Chavez, C., Song, B.: Dynamical models of tuberculosis and their applications. Math. Biosci. Eng. 1(2), 361–404 (2004)

    MATH  MathSciNet  Google Scholar 

  7. Castillo-Chavez, C., Feng, Z., Huang, W.: On the computation of R0 and its role on global stability. In: Castillo-Chavez, C., et al. (eds.) Mathematical Approaches for Emerging and Reemerging Infectious Diseases: An Introduction, vol. 125, pp. 229–250. IMA (2002)

  8. Chitnis, N., Hyman, J.M., Cushing, J.M.: Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model. Bull. Math. Biol. 70, 1272–1296 (2008)

    Article  MATH  MathSciNet  Google Scholar 

  9. Crepaz, N., Marks, G.: Serostatus disclosure, sexual communication and safer sex in HIV-positive men. AIDS Care 15, 379–387 (2003)

    Article  Google Scholar 

  10. de Walque, D.: How does the impact of an HIV/AIDS information campaign vary with educational attainment? Evidence from rural Uganda. J. Dev. Econ. 84, 686–714 (2007)

    Article  Google Scholar 

  11. Eneh, F.O.: Appreciating the multiplier effect of poverty on HIV/AIDS in a resource poor setting. In: Int. Conf. AIDS, Bangkok, Thailand (2004)

  12. Flanagan, J.: South African men rape babies as ‘cure’ for Aids. Telegraph. http://www.telegraph.co.uk/news/worldnews/africaandindianocean/southafrica/1362134/South-African-men-rape-babies-as-%27cure%27-for-Aids.html. Retrieved on 2009-03-25 (2001-11-11)

  13. Granich, R.M., Gilks, C.F., Dye, C., De Cock, K.M., Williams, B.G.: Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. The Lancet 373, 48–57 (2009)

    Article  Google Scholar 

  14. Groce, N.E., Trasi, R.: Rape of individuals with disability: AIDS and the folk belief of virgin cleansing. Lancet 363, 1663–1664. PMID 15158626 (2004)

    Article  Google Scholar 

  15. Hsu Schmitz, S.F.: Effects of treatment or/and vaccination on HIV transmission in homosexuals with genetic heterogeneity. Math. Biosci. 167, 1–18 (2000)

    Article  MATH  Google Scholar 

  16. Joshi, H., Lenhart, S., Albright, K., Gipson, K.: Modeling the effect of information campaigns on the HIV epidemic in Uganda. Math. Biosci. Eng. 5(4), 757–770 (2008)

    Article  MATH  MathSciNet  Google Scholar 

  17. Kimbir, A.R., Oduwole, H.K.: A mathematical model of HIV/AIDS transmission dynamics considering counselling and antiretroviral therapy. J. Mod. Math. Stat. 2(5), 166–169 (2008)

    MathSciNet  Google Scholar 

  18. Klitzman, R., Exner, T., Correale, J., Kirshenbaum, S.B., Remien, R., Ehrhardt, A.A., Lightfoot, M., Catz, S.L., Weinhardt, L.S., Johnson, M.O., Morin, S.F., Rotheram-Borus, M.J., Kelly, J.A., Charlebois, E.: It’s not just what you say: relationships of HIV disclosure and risk reduction among MSM in the post-HAART era. AIDS Care 19, 749–756 (2007)

    Article  Google Scholar 

  19. Korobeinikov, A.: Lyapunov functions and global stability for SIR and SIRS epidemiological models with non-linear transmission. Bull. Math. Biol. 30, 615–626 (2006)

    Article  MathSciNet  Google Scholar 

  20. Meel, B.L.: The myth of child rape as a cure for HIV/AIDS in Transkei: a case report. Med. Sci. Law 43, 85–88. PMID 12627683 (2003)

    Article  Google Scholar 

  21. Mukandavire, Z., Garira, W., Tchuenche, J.M.: Modelling effects of educational campaigns on HIV/AIDS transmission dynamics. Appl. Math. Model. 33, 2084–2095 (2009)

    Article  MATH  MathSciNet  Google Scholar 

  22. Musgrave, J., Watmough, J.: Examination of a simple model of condom usage and individual withdrawal for the HIV epidemic. Math. Biosci. Eng. 6(2), 363–376 (2009)

    Article  MATH  MathSciNet  Google Scholar 

  23. Parsons, J.T., Schrimshaw, E.W., Bimbi, D.S., Wolitski, R.J., Gómez, C.A., Halkitis, P.N.: Consistent, inconsistent, and non-disclosure to casual sex partners among HIV-seropositive gay and bisexual men. AIDS 19, S87–S97 (2005)

    Article  Google Scholar 

  24. Pedamallu, C.S., Ozdamar, L., Kropat, E., Weber, G.-W.: A system dynamics model for intentional transmission of HIV/AIDS using cross impact analysis. http://www3.iam.metu.edu.tr/iam/images/e/eb/Preprint141.pdf. Accessed 30 April 2010.

  25. Simoni, J.M., Pantalone, D.: Secrets and safety in the age of AIDS: does HIV disclosure lead to safer sex? Top. HIV Med. 12, 109–118 (2004)

    Google Scholar 

  26. Stratford, D., Mizuno, Y., Williams, K., Courtenay-Quirk, C., O’Leary, A.: Addressing poverty as risk for disease: recommendations from CDC’s consultation on microenterprise as HIV prevention. Public Health Rep. 123, 9–20 (2003)

    Google Scholar 

  27. Sturmer, M., Doerr, H.W., Berger, A., Gale, P.: Is transmission of HIV in non-viraemic serodiscordant couples possible? Antivir. Ther. 13 729–732 (2008)

    Google Scholar 

  28. Thieme, H.R.: Mathematics in population biology. Princeton University Press, Princeton and Oxford (2003)

    MATH  Google Scholar 

  29. Thorpe, L.E., Frederick, M., Pitt, J., Cheng, I., Watts, D.H., Buschur, S., Green, K., Zorrilla, C., Landesman, S.H., Hershow, R.C.: Effect of hard-drug use on CD4 cell percentage, HIV RNA level, and progression to AIDS-defining class C events among HIV-infected women. J. Acquir. Immune Defic. Syndr. 37(3), 1423–1430 (2004)

    Article  Google Scholar 

  30. van den Driessche, P., Watmough, J.: Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. Math. Biosci. 29–48 (2002)

  31. Wolitski, R.J., Parsons, J.T., Gómez, C.A., Morin, S.F., Maiorana, A.: Prevention with HIV-seropositive men who have sex with men: lessons from the seropositive urban men’s study and the seropositive urban men’s intervention trial. J. AIDS 37, S101–S109 (2004)

    Google Scholar 

  32. UNAIDS: Report on the Global AIDS Epidemic: 4th Global Report (2004)

  33. UNAIDS: Global AIDS Epidemic Continues to Grow, vol. 9, no. 1. http://www.info.gov.hk/aids/archives/node/node0703.pdf (2007)

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Bhunu, C.P., Mushayabasa, S., Kojouharov, H. et al. Mathematical Analysis of an HIV/AIDS Model: Impact of Educational Programs and Abstinence in Sub-Saharan Africa. J Math Model Algor 10, 31–55 (2011). https://doi.org/10.1007/s10852-010-9134-0

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  • DOI: https://doi.org/10.1007/s10852-010-9134-0

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