"Systems biology's multiple maths." Editorial, Nature, 19 October 2000, page 819.
This brief editorial highlights two current efforts to build mathematical models of biological systems: that of Leroy Hood's Institute for Systems Biology in Seattle, and that of Al Gilman's Alliance for Cellular Signalling in Dallas. The former aims to create models of specific cell processes, such as immune responses and perhaps eventually to create a "virtual cell." The latter will try to characterize protein-protein interactions to create a cellular wiring diagram. The editorial concludes: "[P]rovided they and others like them maintain their flexibility to adapt, they should achieve a long-awaited development when mathematics does what it has so often done in other disciplines: provide a basis for prediction and thereby lead rather than lag behind the experiments."
--- Allyn Jackson