On blowup dynamics in the Keller–Segel model of chemotaxis
HTML articles powered by AMS MathViewer
- by S. I. Dejak, D. Egli, P. M. Lushnikov and I. M. Sigal
- St. Petersburg Math. J. 25 (2014), 547-574
- DOI: https://doi.org/10.1090/S1061-0022-2014-01306-4
- Published electronically: June 5, 2014
- PDF | Request permission
Abstract:
The (reduced) Keller–Segel equations modeling chemotaxis of bio-organisms are investigated. A formal derivation and partial rigorous results of the blowup dynamics are presented for solutions of these equations describing the chemotactic aggregation of the organisms. The results are confirmed by numerical simulations, and the formula derived coincides with the formula of Herrero and Velázquez for specially constructed solutions.References
- Mark Alber, Nan Chen, Tilmann Glimm, and Pavel M. Lushnikov, Multiscale dynamics of biological cells with chemotactic interactions: from a discrete stochastic model to a continuous description, Phys. Rev. E (3) 73 (2006), no. 5, 051901, 11. MR 2242588, DOI 10.1103/PhysRevE.73.051901
- M. Alber, N. Chen, P. M. Lushnikov, and S. A. Newman, Continuous macroscopic limit of a discrete stochastic model for interaction of living cells, Phys. Rev. Lett. 99 (2007), 168102.
- William Beckner, Sharp Sobolev inequalities on the sphere and the Moser-Trudinger inequality, Ann. of Math. (2) 138 (1993), no. 1, 213–242. MR 1230930, DOI 10.2307/2946638
- Andrea L. Bertozzi, José A. Carrillo, and Thomas Laurent, Blow-up in multidimensional aggregation equations with mildly singular interaction kernels, Nonlinearity 22 (2009), no. 3, 683–710. MR 2480108, DOI 10.1088/0951-7715/22/3/009
- P. Biler, Growth and accretion of mass in an astrophysical model, Appl. Math. (Warsaw) 23 (1995), no. 2, 179–189. MR 1341221, DOI 10.4064/am-23-2-179-189
- Piotr Biler, Local and global solvability of some parabolic systems modelling chemotaxis, Adv. Math. Sci. Appl. 8 (1998), no. 2, 715–743. MR 1657160
- P. Biler, G. Karch, and P. Laurencot, The $8\pi$-problem for radially symmetric solutions of a chemotaxis model in the plane, Preprint, 2006.
- P. Bizoń, Yu. N. Ovchinnikov, and I. M. Sigal, Collapse of an instanton, Nonlinearity 17 (2004), no. 4, 1179–1191. MR 2069700, DOI 10.1088/0951-7715/17/4/003
- Adrien Blanchet, Jean Dolbeault, and Benoît Perthame, Two-dimensional Keller-Segel model: optimal critical mass and qualitative properties of the solutions, Electron. J. Differential Equations (2006), No. 44, 32. MR 2226917
- Adrien Blanchet, Eric A. Carlen, and José A. Carrillo, Functional inequalities, thick tails and asymptotics for the critical mass Patlak-Keller-Segel model, J. Funct. Anal. 262 (2012), no. 5, 2142–2230. MR 2876403, DOI 10.1016/j.jfa.2011.12.012
- Adrien Blanchet, José A. Carrillo, and Philippe Laurençot, Critical mass for a Patlak-Keller-Segel model with degenerate diffusion in higher dimensions, Calc. Var. Partial Differential Equations 35 (2009), no. 2, 133–168. MR 2481820, DOI 10.1007/s00526-008-0200-7
- Adrien Blanchet, José A. Carrillo, and Nader Masmoudi, Infinite time aggregation for the critical Patlak-Keller-Segel model in $\Bbb R^2$, Comm. Pure Appl. Math. 61 (2008), no. 10, 1449–1481. MR 2436186, DOI 10.1002/cpa.20225
- Adrien Blanchet, Jean Dolbeault, Miguel Escobedo, and Javier Fernández, Asymptotic behaviour for small mass in the two-dimensional parabolic-elliptic Keller-Segel model, J. Math. Anal. Appl. 361 (2010), no. 2, 533–542. MR 2568716, DOI 10.1016/j.jmaa.2009.07.034
- J. T. Bonner, The cellular slime molds, Princeton Univ. Press, Princeton, NJ, 1967.
- Michael P. Brenner, Peter Constantin, Leo P. Kadanoff, Alain Schenkel, and Shankar C. Venkataramani, Diffusion, attraction and collapse, Nonlinearity 12 (1999), no. 4, 1071–1098. MR 1709861, DOI 10.1088/0951-7715/12/4/320
- M. P. Brenner, L. S. Levitov, and E. O. Budrene, Physical mechanisms for chemotactic pattern formation by bacteria, Biophys. J. 74 (1998), 1677–1693.
- V. S. Buslaev and G. S. Perel′man, On the stability of solitary waves for nonlinear Schrödinger equations, Nonlinear evolution equations, Amer. Math. Soc. Transl. Ser. 2, vol. 164, Amer. Math. Soc., Providence, RI, 1995, pp. 75–98. MR 1334139, DOI 10.1090/trans2/164/04
- Vladimir S. Buslaev and Catherine Sulem, On asymptotic stability of solitary waves for nonlinear Schrödinger equations, Ann. Inst. H. Poincaré C Anal. Non Linéaire 20 (2003), no. 3, 419–475 (English, with English and French summaries). MR 1972870, DOI 10.1016/S0294-1449(02)00018-5
- E. Carlen and M. Loss, Competing symmetries, the logarithmic HLS inequality and Onofri’s inequality on $S^n$, Geom. Funct. Anal. 2 (1992), no. 1, 90–104. MR 1143664, DOI 10.1007/BF01895706
- Eric A. Carlen and Alessio Figalli, Stability for a GNS inequality and the log-HLS inequality, with application to the critical mass Keller-Segel equation, Duke Math. J. 162 (2013), no. 3, 579–625. MR 3024094, DOI 10.1215/00127094-2019931
- P. Carmeliet, Mechanisms of angiogenesis and arteriogenesis, Nat. Med. 6 (2000), 389–395.
- José A. Carrillo, Massimo Fornasier, Giuseppe Toscani, and Francesco Vecil, Particle, kinetic, and hydrodynamic models of swarming, Mathematical modeling of collective behavior in socio-economic and life sciences, Model. Simul. Sci. Eng. Technol., Birkhäuser Boston, Boston, MA, 2010, pp. 297–336. MR 2744704, DOI 10.1007/978-0-8176-4946-3_{1}2
- Pierre-Henri Chavanis and Clément Sire, Exact analytical solution of the collapse of self-gravitating Brownian particles and bacterial populations at zero temperature, Phys. Rev. E (3) 83 (2011), no. 3, 031131, 20. MR 2788232, DOI 10.1103/PhysRevE.83.031131
- S. Childress and J. K. Percus, Nonlinear aspects of chemotaxis, Math. Biosci. 56 (1981), no. 3-4, 217–237. MR 632161, DOI 10.1016/0025-5564(81)90055-9
- P. Constantin, I. G. Kevrekidis, and E. S. Titi, Asymptotic states of a Smoluchowski equation, Arch. Ration. Mech. Anal. 174 (2004), no. 3, 365–384. MR 2107775, DOI 10.1007/s00205-004-0331-8
- Peter Constantin, Ioannis Kevrekidis, and Edriss S. Titi, Remarks on a Smoluchowski equation, Discrete Contin. Dyn. Syst. 11 (2004), no. 1, 101–112. MR 2073948, DOI 10.3934/dcds.2004.11.101
- H. L. Cycon, R. G. Froese, W. Kirsch, and B. Simon, Schrödinger operators with application to quantum mechanics and global geometry, Springer Study Edition, Texts and Monographs in Physics, Springer-Verlag, Berlin, 1987. MR 883643
- Steven Dejak, Zhou Gang, Israel Michael Sigal, and Shuangcai Wang, Blow-up in nonlinear heat equations, Adv. in Appl. Math. 40 (2008), no. 4, 433–481. MR 2412155, DOI 10.1016/j.aam.2007.04.003
- S. I. Dejak, P. M. Lushnikov, Yu. N. Ovchinnikov, and I. M. Sigal, On spectra of linearized operators for Keller-Segel models of chemotaxis, Phys. D 241 (2012), no. 15, 1245–1254. MR 2930725, DOI 10.1016/j.physd.2012.04.003
- M. Doi, Molecular dynamics and rheological properties of concentrated solutions of rodlike polymers in isotropic and liquid crystalline phases, J. Polym. Sci., 19 (1981), 229–243.
- S. A. Dyachenko, P. M. Lushnikov, and N. Vladimirova, Logarithmic-type scaling of the collapse of Keller–Segel equation, AIP Conf. Proc. 1389 (2011), 709–712.
- Herbert Gajewski and Klaus Zacharias, Global behaviour of a reaction-diffusion system modelling chemotaxis, Math. Nachr. 195 (1998), 77–114. MR 1654677, DOI 10.1002/mana.19981950106
- Zhou Gang and I. M. Sigal, On soliton dynamics in nonlinear Schrödinger equations, Geom. Funct. Anal. 16 (2006), no. 6, 1377–1390. MR 2276543, DOI 10.1007/s00039-006-0587-2
- Zhou Gang and I. M. Sigal, Relaxation of solitons in nonlinear Schrödinger equations with potential, Adv. Math. 216 (2007), no. 2, 443–490. MR 2351368, DOI 10.1016/j.aim.2007.04.018
- Stephen J. Gustafson and Israel Michael Sigal, Mathematical concepts of quantum mechanics, 2nd ed., Universitext, Springer, Heidelberg, 2011. MR 3012853, DOI 10.1007/978-3-642-21866-8
- Miguel A. Herrero and Juan J. L. Velázquez, Chemotactic collapse for the Keller-Segel model, J. Math. Biol. 35 (1996), no. 2, 177–194. MR 1478048, DOI 10.1007/s002850050049
- Miguel A. Herrero and Juan J. L. Velázquez, Singularity patterns in a chemotaxis model, Math. Ann. 306 (1996), no. 3, 583–623. MR 1415081, DOI 10.1007/BF01445268
- Miguel A. Herrero and Juan J. L. Velázquez, A blow-up mechanism for a chemotaxis model, Ann. Scuola Norm. Sup. Pisa Cl. Sci. (4) 24 (1997), no. 4, 633–683 (1998). MR 1627338
- M. A. Herrero, E. Medina, and J. J. L. Velázquez, Finite-time aggregation into a single point in a reaction-diffusion system, Nonlinearity 10 (1997), no. 6, 1739–1754. MR 1483563, DOI 10.1088/0951-7715/10/6/016
- M. A. Herrero, E. Medina, and J. J. L. Velázquez, Self-similar blow-up for a reaction-diffusion system, J. Comput. Appl. Math. 97 (1998), no. 1-2, 99–119. MR 1651769, DOI 10.1016/S0377-0427(98)00104-6
- T. Hillen and K. J. Painter, A user’s guide to PDE models for chemotaxis, J. Math. Biol. 58 (2009), no. 1-2, 183–217. MR 2448428, DOI 10.1007/s00285-008-0201-3
- Dirk Horstmann, The nonsymmetric case of the Keller-Segel model in chemotaxis: some recent results, NoDEA Nonlinear Differential Equations Appl. 8 (2001), no. 4, 399–423. MR 1867320, DOI 10.1007/PL00001455
- Dirk Horstmann, On the existence of radially symmetric blow-up solutions for the Keller-Segel model, J. Math. Biol. 44 (2002), no. 5, 463–478. MR 1908133, DOI 10.1007/s002850100134
- Dirk Horstmann, From 1970 until present: the Keller-Segel model in chemotaxis and its consequences. I, Jahresber. Deutsch. Math.-Verein. 105 (2003), no. 3, 103–165. MR 2013508
- Dirk Horstmann, From 1970 until present: the Keller-Segel model in chemotaxis and its consequences. II, Jahresber. Deutsch. Math.-Verein. 106 (2004), no. 2, 51–69. MR 2073515
- Dirk Horstmann and Guofang Wang, Blow-up in a chemotaxis model without symmetry assumptions, European J. Appl. Math. 12 (2001), no. 2, 159–177. MR 1931303, DOI 10.1017/S0956792501004363
- Dirk Horstmann and Michael Winkler, Boundedness vs. blow-up in a chemotaxis system, J. Differential Equations 215 (2005), no. 1, 52–107. MR 2146345, DOI 10.1016/j.jde.2004.10.022
- W. Jäger and S. Luckhaus, On explosions of solutions to a system of partial differential equations modelling chemotaxis, Trans. Amer. Math. Soc. 329 (1992), no. 2, 819–824. MR 1046835, DOI 10.1090/S0002-9947-1992-1046835-6
- E. F. Keller and L. A. Segel, Initiation of slime mold aggregation viewed as an instability, J. Theor. Biol. 26 (1970), 300–415.
- J. Krieger, W. Schlag, and D. Tataru, Renormalization and blow up for charge one equivariant critical wave maps, Invent. Math. 171 (2008), no. 3, 543–615. MR 2372807, DOI 10.1007/s00222-007-0089-3
- —, Renormalization and blow up for critical Yang–Mills problem, e-print, 2008; arXiv:0809.211, 2008.
- R. G. Larson, The structure and rheology of complex fluids, Oxford Univ. Press, London, 1999.
- P. M. Lushnikov, Critical chemotactic collapse, Phys. Lett. A 374 (2010), 1678–1685.
- P. M. Lushnikov, N. Chen, and M. Alber, Macroscopic dynamics of biological cells interacting via chemotaxis and direct contact, Phys. Rev. E 78 (2008), no. 6, 061904, 12 pp.
- Frank Merle and Pierre Raphaël, Blow up of the critical norm for some radial $L^2$ super critical nonlinear Schrödinger equations, Amer. J. Math. 130 (2008), no. 4, 945–978. MR 2427005, DOI 10.1353/ajm.0.0012
- Frank Merle and Hatem Zaag, Blow-up behavior outside the origin for a semilinear wave equation in the radial case, Bull. Sci. Math. 135 (2011), no. 4, 353–373. MR 2799813, DOI 10.1016/j.bulsci.2011.03.001
- V. Nanjundiah, Chemotaxis, signal relaying and aggregation morphology, J. Theor. Biol. 42 (1973), 63–105.
- Toshitaka Nagai, Blow-up of radially symmetric solutions to a chemotaxis system, Adv. Math. Sci. Appl. 5 (1995), no. 2, 581–601. MR 1361006
- Toshitaka Nagai, Blowup of nonradial solutions to parabolic-elliptic systems modeling chemotaxis in two-dimensional domains, J. Inequal. Appl. 6 (2001), no. 1, 37–55. MR 1887324, DOI 10.1155/S1025583401000042
- Toshitaka Nagai, Global existence and blowup of solutions to a chemotaxis system, Proceedings of the Third World Congress of Nonlinear Analysts, Part 2 (Catania, 2000), 2001, pp. 777–787. MR 1970697, DOI 10.1016/S0362-546X(01)00222-X
- Toshitaka Nagai and Takasi Senba, Behavior of radially symmetric solutions of a system related to chemotaxis, Proceedings of the Second World Congress of Nonlinear Analysts, Part 6 (Athens, 1996), 1997, pp. 3837–3842. MR 1602939, DOI 10.1016/S0362-546X(96)00256-8
- Toshitaka Nagai and Takasi Senba, Global existence and blow-up of radial solutions to a parabolic-elliptic system of chemotaxis, Adv. Math. Sci. Appl. 8 (1998), no. 1, 145–156. MR 1623326
- Toshitaka Nagai, Takasi Senba, and Takashi Suzuki, Chemotactic collapse in a parabolic system of mathematical biology, Hiroshima Math. J. 30 (2000), no. 3, 463–497. MR 1799300
- Toshitaka Nagai, Takasi Senba, and Kiyoshi Yoshida, Application of the Trudinger-Moser inequality to a parabolic system of chemotaxis, Funkcial. Ekvac. 40 (1997), no. 3, 411–433. MR 1610709
- T. J. Newman and R. Grima, Many-body theory of chemotactic cell-cell interactions, Phys. Rev. E 70 (2004), no. 5, 051916, 15 pp.
- Karl Oelschläger, On the derivation of reaction-diffusion equations as limit dynamics of systems of moderately interacting stochastic processes, Probab. Theory Related Fields 82 (1989), no. 4, 565–586. MR 1002901, DOI 10.1007/BF00341284
- J. Ostriker, The equilibrium of polytropic and isothermal cylinders, Astrophys. J. 140 (1964), 1056–1066. MR 189788, DOI 10.1086/148005
- Hans G. Othmer and Angela Stevens, Aggregation, blowup, and collapse: the ABCs of taxis in reinforced random walks, SIAM J. Appl. Math. 57 (1997), no. 4, 1044–1081. MR 1462051, DOI 10.1137/S0036139995288976
- Yu. N. Ovchinnikov and I. M. Sigal, On collapse of wave maps, Phys. D 240 (2011), no. 17, 1311–1324. MR 2831768, DOI 10.1016/j.physd.2011.04.014
- Clifford S. Patlak, Random walk with persistence and external bias, Bull. Math. Biophys. 15 (1953), 311–338. MR 81586, DOI 10.1007/bf02476407
- Benoît Perthame, Transport equations in biology, Frontiers in Mathematics, Birkhäuser Verlag, Basel, 2007. MR 2270822
- P. Rafael and I. Rodnianski, Stable blow up dynamics for the critical co-rotational wave maps and equivariant Yang–Mills problems, arXiv:0911.0692, 2010.
- Michael Reed and Barry Simon, Methods of modern mathematical physics. IV. Analysis of operators, Academic Press [Harcourt Brace Jovanovich, Publishers], New York-London, 1978. MR 0493421
- Igor Rodnianski and Jacob Sterbenz, On the formation of singularities in the critical $\textrm {O}(3)$ $\sigma$-model, Ann. of Math. (2) 172 (2010), no. 1, 187–242. MR 2680419, DOI 10.4007/annals.2010.172.187
- Clément Sire and Pierre-Henri Chavanis, Critical dynamics of self-gravitating Langevin particles and bacterial populations, Phys. Rev. E (3) 78 (2008), no. 6, 061111, 22. MR 2546057, DOI 10.1103/PhysRevE.78.061111
- A. Soffer and M. I. Weinstein, Multichannel nonlinear scattering for nonintegrable equations, Comm. Math. Phys. 133 (1990), no. 1, 119–146. MR 1071238
- A. Soffer and M. I. Weinstein, Multichannel nonlinear scattering for nonintegrable equations. II. The case of anisotropic potentials and data, J. Differential Equations 98 (1992), no. 2, 376–390. MR 1170476, DOI 10.1016/0022-0396(92)90098-8
- A. Soffer and M. I. Weinstein, Selection of the ground state for nonlinear Schrödinger equations, Rev. Math. Phys. 16 (2004), no. 8, 977–1071. MR 2101776, DOI 10.1142/S0129055X04002175
- Angela Stevens, The derivation of chemotaxis equations as limit dynamics of moderately interacting stochastic many-particle systems, SIAM J. Appl. Math. 61 (2000), no. 1, 183–212. MR 1776393, DOI 10.1137/S0036139998342065
- Michael Struwe, Equivariant wave maps in two space dimensions, Comm. Pure Appl. Math. 56 (2003), no. 7, 815–823. Dedicated to the memory of Jürgen K. Moser. MR 1990477, DOI 10.1002/cpa.10074
- Catherine Sulem and Pierre-Louis Sulem, The nonlinear Schrödinger equation, Applied Mathematical Sciences, vol. 139, Springer-Verlag, New York, 1999. Self-focusing and wave collapse. MR 1696311
- Tai-Peng Tsai and Horng-Tzer Yau, Asymptotic dynamics of nonlinear Schrödinger equations: resonance-dominated and dispersion-dominated solutions, Comm. Pure Appl. Math. 55 (2002), no. 2, 153–216. MR 1865414, DOI 10.1002/cpa.3012
- Tai-Peng Tsai and Horng-Tzer Yau, Relaxation of excited states in nonlinear Schrödinger equations, Int. Math. Res. Not. 31 (2002), 1629–1673. MR 1916427, DOI 10.1155/S1073792802201063
- Tai-Peng Tsai and Horng-Tzer Yau, Stable directions for excited states of nonlinear Schrödinger equations, Comm. Partial Differential Equations 27 (2002), no. 11-12, 2363–2402. MR 1944033, DOI 10.1081/PDE-120016161
- J. J. L. Velázquez, Stability of some mechanisms of chemotactic aggregation, SIAM J. Appl. Math. 62 (2002), no. 5, 1581–1633. MR 1918569, DOI 10.1137/S0036139900380049
- J. J. L. Velázquez, Point dynamics in a singular limit of the Keller-Segel model. I. Motion of the concentration regions, SIAM J. Appl. Math. 64 (2004), no. 4, 1198–1223. MR 2068667, DOI 10.1137/S0036139903433888
- G. Wolansky, On steady distributions of self-attracting clusters under friction and fluctuations, Arch. Rational Mech. Anal. 119 (1992), no. 4, 355–391. MR 1179691, DOI 10.1007/BF01837114
Bibliographic Information
- S. I. Dejak
- Affiliation: Department of Mathematics, University of Toronto, Toronto, Canada
- Email: steven.dejak@gmail.com
- D. Egli
- Affiliation: Department of Mathematics, University of Toronto, Toronto, Canada
- Email: daniel.egli2@gmail.com
- P. M. Lushnikov
- Affiliation: Department of Mathematics and Statistics, University of New Mexico
- Email: plushnik@math.unm.edu
- I. M. Sigal
- Affiliation: Department of Mathematics, University of Toronto, Toronto, Canada
- MR Author ID: 161895
- Email: im.sigal@utoronto.ca
- Received by editor(s): December 1, 2012
- Published electronically: June 5, 2014
- Additional Notes: The research of the second and fourth authors was partially supported by NSERC under Grant NA7901, and of the third author, by NSF under Grants DMS 0719895 and DMS 0807131
- © Copyright 2014 American Mathematical Society
- Journal: St. Petersburg Math. J. 25 (2014), 547-574
- MSC (2010): Primary 35K51, 35K57, 35Q84, 35Q92
- DOI: https://doi.org/10.1090/S1061-0022-2014-01306-4
- MathSciNet review: 3184616
Dedicated: In memory of V. S. Buslaev, a scientist and a friend