|
Symmetry-breaking bifurcation of analytic solutions to free boundary problems: An application to a model of tumor growth
Author(s):
Avner
Friedman;
Fernando
Reitich
Journal:
Trans. Amer. Math. Soc.
353
(2001),
1587-1634.
MSC (1991):
Primary 35B32, 35R35;
Secondary 35B30, 35B60, 35C10, 35J85, 35Q80, 92C15, 95C15
Posted:
November 21, 2000
Retrieve article in:
PDF DVI PostScript
This article is available free of charge
Abstract |
References |
Similar articles |
Additional information
Abstract:
In this paper we develop a general technique for establishing analyticity of solutions of partial differential equations which depend on a parameter . The technique is worked out primarily for a free boundary problem describing a model of a stationary tumor. We prove the existence of infinitely many branches of symmetry-breaking solutions which bifurcate from any given radially symmetric steady state; these asymmetric solutions are analytic jointly in the spatial variables and in .
References:
- 1.
- J.A. Adam, General aspects of modeling tumor growth and immune response, in A Survey of Models for Tumor-Immune System Dynamics, J.A. Adam and N. Bellomo, eds., Birkhäuser, Boston (1996), 15-87.
- 2.
- R.A. Adams, Sobolev Spaces, Academic Press, New York (1975). MR 56:9247
- 3.
- O. Bruno and P. Laurence, Existence of three-dimensional toroidal MHD equilibria with nonconstant pressure, Comm. Pure Appl. Math., 49 (1996), 717-764. MR 97g:35137
- 4.
- O. Bruno and F. Reitich, Solution of the boundary value problem for the Helmholz equation via variation of the boundary into the complex domain, Proc. Roy. Soc. Edinburgh, Sec. A 122 (1992), 317-340. MR 94e:35131
- 5.
- H.M. Byrne, The importance of intercellular adhesion in the development of carcinomas, IMA J. Math. Appl. Med. and Biol., 14 (1997), 305-323.
- 6.
- H.M. Byrne, The effect of time delays on the dynamics of avascular tumor growth, Math. Biosciences, 144 (1997), 83-117. MR 98h:92014
- 7.
- H.M. Byrne and M.A.J. Chaplain, Growth of necrotic tumors in the presence and absence of inhibitors, Math. Biosciences, 135 (1996), 187-216.
- 8.
- M.A.J. Chaplain, The development of a spatial pattern in a model for cancer growth, in Experimental and Theoretical Advances in Biological Pattern Formation, H.G. Othmer, P.K. Maini and J.D. Murray eds., Plenum Press (1993), 45-59. MR 22:9739
- 9.
- A. Friedman, On the regularity of solutions of nonlinear elliptic and parabolic systems of partial differential equations, J. Math. Mech., 7 (1958), 43-60.
- 10.
- A. Friedman and F. Reitich, Analysis of a mathematical model for the growth of tumors, J. Math. Biol., 38 (1999), 262-284. CMP 99:11
- 11.
- A. Friedman and F. Reitich, Nonlinear stability of a quasi-static Stefan problem with surface tension: a continuation approach, to appear.
- 12.
- H.P. Greenspan, On the growth and stability of cell cultures and solid tumors, Theor. Biol., 56 (1976), 229-242. MR 55:2183
- 13.
- D.L.S. McElwain and L.E. Morris, Apoptosis as a volume loss mechanism in mathematical models of solid tumor growth, Math. Biosciences, 39 (1978), 147-157.
- 14.
- D.H Sattinger, Group-Theoretic Methods in Bifurcation Theory, Lecture Notes in Mathematics, 762, Springer-Verlag, Berlin (1979). MR 81e:58022
- 15.
- J. Smoller, Shock Waves and Reaction-Diffusion Equations, Springer-Verlag, New York (1983). MR 84d:35002
- 16.
- G.N. Watson, A Treatise on the Theory of Bessel Functions, Second Edition, Cambridge University Press (1944). MR 6:64a
Similar Articles:
Retrieve articles in Transactions of the American Mathematical Society
with MSC
(1991):
35B32, 35R35,
35B30, 35B60, 35C10, 35J85, 35Q80, 92C15, 95C15
Retrieve articles in all Journals with MSC
(1991):
35B32, 35R35,
35B30, 35B60, 35C10, 35J85, 35Q80, 92C15, 95C15
Additional Information:
Avner
Friedman
Affiliation:
School of Mathematics, University of Minnesota, Minneapolis, Minnesota 55455
Email:
friedman@math.umn.edu
Fernando
Reitich
Affiliation:
School of Mathematics, University of Minnesota, Minneapolis, Minnesota 55455
Email:
reitich@math.umn.edu
DOI:
10.1090/S0002-9947-00-02715-X
PII:
S 0002-9947(00)02715-X
Keywords:
Free boundary problem,
steady states,
bifurcation,
symmetry-breaking,
analytic solutions,
tumor growth
Received by editor(s):
August 17, 1999
Posted:
November 21, 2000
Copyright of article:
Copyright
2000,
American Mathematical Society
|