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Transactions of the American Mathematical Society
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Symmetry-breaking bifurcation of analytic solutions to free boundary problems: An application to a model of tumor growth

Author(s): Avner Friedman; Fernando Reitich
Journal: Trans. Amer. Math. Soc. 353 (2001), 1587-1634.
MSC (1991): Primary 35B32, 35R35; Secondary 35B30, 35B60, 35C10, 35J85, 35Q80, 92C15, 95C15
Posted: November 21, 2000
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Abstract | References | Similar articles | Additional information

Abstract: In this paper we develop a general technique for establishing analyticity of solutions of partial differential equations which depend on a parameter $\varepsilon$. The technique is worked out primarily for a free boundary problem describing a model of a stationary tumor. We prove the existence of infinitely many branches of symmetry-breaking solutions which bifurcate from any given radially symmetric steady state; these asymmetric solutions are analytic jointly in the spatial variables and in $\varepsilon$.


References:

1.
J.A. Adam, General aspects of modeling tumor growth and immune response, in A Survey of Models for Tumor-Immune System Dynamics, J.A. Adam and N. Bellomo, eds., Birkhäuser, Boston (1996), 15-87.

2.
R.A. Adams, Sobolev Spaces, Academic Press, New York (1975). MR 56:9247

3.
O. Bruno and P. Laurence, Existence of three-dimensional toroidal MHD equilibria with nonconstant pressure, Comm. Pure Appl. Math., 49 (1996), 717-764. MR 97g:35137

4.
O. Bruno and F. Reitich, Solution of the boundary value problem for the Helmholz equation via variation of the boundary into the complex domain, Proc. Roy. Soc. Edinburgh, Sec. A 122 (1992), 317-340. MR 94e:35131

5.
H.M. Byrne, The importance of intercellular adhesion in the development of carcinomas, IMA J. Math. Appl. Med. and Biol., 14 (1997), 305-323.

6.
H.M. Byrne, The effect of time delays on the dynamics of avascular tumor growth, Math. Biosciences, 144 (1997), 83-117. MR 98h:92014

7.
H.M. Byrne and M.A.J. Chaplain, Growth of necrotic tumors in the presence and absence of inhibitors, Math. Biosciences, 135 (1996), 187-216.

8.
M.A.J. Chaplain, The development of a spatial pattern in a model for cancer growth, in Experimental and Theoretical Advances in Biological Pattern Formation, H.G. Othmer, P.K. Maini and J.D. Murray eds., Plenum Press (1993), 45-59. MR 22:9739

9.
A. Friedman, On the regularity of solutions of nonlinear elliptic and parabolic systems of partial differential equations, J. Math. Mech., 7 (1958), 43-60.

10.
A. Friedman and F. Reitich, Analysis of a mathematical model for the growth of tumors, J. Math. Biol., 38 (1999), 262-284. CMP 99:11

11.
A. Friedman and F. Reitich, Nonlinear stability of a quasi-static Stefan problem with surface tension: a continuation approach, to appear.

12.
H.P. Greenspan, On the growth and stability of cell cultures and solid tumors, Theor. Biol., 56 (1976), 229-242. MR 55:2183

13.
D.L.S. McElwain and L.E. Morris, Apoptosis as a volume loss mechanism in mathematical models of solid tumor growth, Math. Biosciences, 39 (1978), 147-157.

14.
D.H Sattinger, Group-Theoretic Methods in Bifurcation Theory, Lecture Notes in Mathematics, 762, Springer-Verlag, Berlin (1979). MR 81e:58022

15.
J. Smoller, Shock Waves and Reaction-Diffusion Equations, Springer-Verlag, New York (1983). MR 84d:35002

16.
G.N. Watson, A Treatise on the Theory of Bessel Functions, Second Edition, Cambridge University Press (1944). MR 6:64a


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Additional Information:

Avner Friedman
Affiliation: School of Mathematics, University of Minnesota, Minneapolis, Minnesota 55455
Email: friedman@math.umn.edu

Fernando Reitich
Affiliation: School of Mathematics, University of Minnesota, Minneapolis, Minnesota 55455
Email: reitich@math.umn.edu

DOI: 10.1090/S0002-9947-00-02715-X
PII: S 0002-9947(00)02715-X
Keywords: Free boundary problem, steady states, bifurcation, symmetry-breaking, analytic solutions, tumor growth
Received by editor(s): August 17, 1999
Posted: November 21, 2000
Copyright of article: Copyright 2000, American Mathematical Society


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