|
A hyperbolic free boundary problem modeling tumor growth: Asymptotic behavior
Author(s):
Xinfu
Chen;
Shangbin
Cui;
Avner
Friedman
Journal:
Trans. Amer. Math. Soc.
357
(2005),
4771-4804.
MSC (2000):
Primary 34B15;
Secondary 35C10, 35Q80, 92C15
Posted:
July 20, 2005
Retrieve article in:
PDF DVI PostScript
Abstract |
References |
Similar articles |
Additional information
Abstract:
In this paper we study a free boundary problem modeling the growth of radially symmetric tumors with two populations of cells: proliferating cells and quiescent cells. The densities of these cells satisfy a system of nonlinear first order hyperbolic equations in the tumor, and the tumor's surface is a free boundary . The nutrient concentration satisfies a diffusion equation, and satisfies an integro-differential equation. It is known that this problem has a unique stationary solution with . We prove that (i) if , then , and (ii) the stationary solution is linearly asymptotically stable.
References:
-
- 1.
- J. Adam, A simplified mathematical model of tumor growth, Math. Biosci. 81 (1986), 224-229.
- 2.
- B. V. Bazaliy and A. Friedman, A free boundary problem for an elliptic-parabolic system: application to a model of tumor growth, Comm. P. D. E. 28 (2003), 627-675. MR 1976462 (2004c:35420)
- 3.
- B. V. Bazaliy and A. Friedman, Global existence and stability for an elliptic-parabolic free boundary problem: an application of a model of tumor growth, Indiana Univ. Math. J. 52 (2003), 1265-1304. MR 2010327 (2004j:35302)
- 4.
- N. Bellomo and L. Preziosi, Modelling and mathematical problems related to tumor evolution and its interaction with the immune system, Mathematical and Computer Modelling 32 (2000), 413-452. MR 1775113 (2001i:92016)
- 5.
- N. Britton and M. Chaplain, A qualitative analysis of some models of tissue growth, Math. Biosci. 113 (1993), 77-89.
- 6.
- H. M. Byrne, A weakly nonlinear analysis of a model of vascular solid tumor growth, J. Math. Biol. 39 (1999), 59-89. MR 1705626 (2000i:92011)
- 7.
- H. Byrne and M. Chaplain, Growth of nonnecrotic tumors in the presence and absence of inhibitors, Math. Biosci. 131 (1995), 130-151.
- 8.
- H. Byrne and M. Chaplain, Growth of necrotic tumors in the presence and absence of inhibitors, Math. Biosci. 135 (1996), 187-216.
- 9.
- H. Byrne and M. Chaplain, Free boundary value problems associated with growth and development of multicellular spheroid, Euro. J. Appl. Math. 8 (1997), 639-658. MR 1608619 (99c:92020)
- 10.
- S. Cui, Analysis of a mathematical model for the growth of tumors under the action of external inhibitors, J. Math. Biol. 44 (2002), 395-426. MR 1908130 (2003f:92019)
- 11.
- S. Cui and A. Friedman, Analysis of a mathematical model of the effect of inhibitors on the growth of tumors, Math. Biosci. 164 (2000), 103-137. MR 1751267 (2001d:92006)
- 12.
- S. Cui and A. Friedman, Analysis of a mathematical model of the growth of necrotic tumors, J. Math. Anal. Appl. 255 (2001), 636-677. MR 1815805 (2002a:35195)
- 13.
- S. Cui and A. Friedman, A free boundary problem for a singular system of differential equations: an application to a model of tumor growth, Trans. Amer. Math. Soc. 355 (2003), 3537-3590. MR 1990162 (2004c:34051)
- 14.
- S. Cui and A. Friedman, A hyperbolic free boundary problem modeling tumor growth, Interfaces and Free Boundaries 5 (2003), 159-182. MR 1980470 (2004b:35342)
- 15.
- A. Friedman and F. Reitich, Analysis of a mathematical model for the growth of tumors, J. Math. Biol. 38 (1999), 262-284. MR 1684873 (2001f:92011)
- 16.
- A. Friedman and F. Reitich, Symmetry-breaking bifurcation of analytic solutions to free boundary problems: an application to a model of tumor growth, Trans. Amer. Math. Soc. 353 (2000), 1587-1634. MR 1806728 (2002a:35208)
- 17.
- A. Friedman and F. Reitich, On the existence of spatially patterned dormant malignancies in the model for the growth of non-necrotic vascular tumor, Math. Models and Methods in Appl. Sci. 11 (2001), 601-625. MR 1832995 (2002c:92012)
- 18.
- H. Greenspan, Models for the growth of solid tumor by diffusion, Stud. Appl. Math. 51 (1972), 317-340.
- 19.
- H. Greenspan, On the growth and stability of cell cultures and solid tumors, J. Theor. Biol. 56 (1976), 229-242. MR 0429164 (55:2183)
- 20.
- D. McElwain and G. Pettet, Cell migration in multicell spheroids: swimming against the tide, Bull. Math. Biol. 55 (1993), 655-674.
- 21.
- G. Pettet, C. P. Please, M. J. Tindall and D. McElwain, The migration of cells in multicell tumor spheroids, Bull. Math. Biol. 63 (2001), 231-257.
- 22.
- J. Sherrat and M. Chaplain, A new mathematical model for avascular tumor growth, J. Math. Biol. 43 (2001), 291-312.
- 23.
- K. Thompson and H. Byrne, Modelling the internalisation of labelled cells in tumor spheroids, Bull. Math. Biol. 61 (1999), 601-623.
- 24.
- J. Ward and J. King, Mathematical modelling of avascular-tumor growth II: Modelling growth saturation, IMA J. Math. Appl. Med. Biol. 15 (1998), 1-42.
Similar Articles:
Retrieve articles in Transactions of the American Mathematical Society
with MSC
(2000):
34B15,
35C10, 35Q80, 92C15
Retrieve articles in all Journals with MSC
(2000):
34B15,
35C10, 35Q80, 92C15
Additional Information:
Xinfu
Chen
Affiliation:
Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
Email:
xinfu@pitt.edu
Shangbin
Cui
Affiliation:
Department of Mathematics, Zhongshan University, Guangzhou, Guangdong 510275, People's Republic of China
Email:
mcinst@zsu.edu.cn
Avner
Friedman
Affiliation:
Department of Mathematics, The Ohio State University, 231 West 18th Avenue, Columbus, Ohio 43210-1174
Email:
afriedman@mbi.osu.edu
DOI:
10.1090/S0002-9947-05-03784-0
PII:
S 0002-9947(05)03784-0
Keywords:
Tumor growth,
free boundary problem,
stationary solution,
asymptotic behavior
Received by editor(s):
September 24, 2002
Posted:
July 20, 2005
Copyright of article:
Copyright
2005,
American Mathematical Society
|