Local degree of separability and invariance of domain

In ${E^n}$ an invariance of domain theorem may be proved assuming the Jordan Brouwer Theorem. In this paper such a theorem is proved for various locally compact, connected, Hausdorff spaces which satisfy a certain local degree of separability property. An example shows the separability condition may not be removed. A second theorem yields additional information about homogeneous spaces which satisfy the hypotheses of the first theorem.