Reduced equations for an active model of hydroelastic waves in the cochlea
Authors:
Jacob Rubinstein and Peter Sternberg
Journal:
Quart. Appl. Math. 79 (2021), 395-408
MSC (2020):
Primary 92-10; Secondary 76M45
DOI:
https://doi.org/10.1090/qam/1584
Published electronically:
October 14, 2020
MathSciNet review:
4288589
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Abstract: Building upon our earlier passive models for the cochlea (see L. Peres Hari, J. Rubinstein, and P. Sternberg [Quart. Appl. Math. 74 (2016), no. 4, 647–670] and J. Rubinstein and P. Sternberg [Pure Appl. Funct. Anal. 5 (2020), no. 2, 457–471]), here we enhance the model with an active mechanism. Starting with a one-chamber simplification leading to a system of a time-dependent PDE in two spatial variables for the pressure coupled to a PDE in one spatial variable for the oscillation of the basilar membrane, we rigorously establish the validity of a dimension reduction to a system to two ODE’s. We then present numerical simulations demonstrating the ability of this reduced active system to distinguish and amplify multi-frequency input signals.
References
- J. Ashmore et al., The remarkable cochlear amplifier, Hearing Res. 266 (2006), 1–17.
- J. Berger and J. Rubinstein, Anatomic set of mechanical models for the organ of Corti, preprint.
- P. Dallos, The active cochlea, J. Neuroscience 12 (1992), 4575–4585.
- CD Geisler, A cochlear model using feedback from motile outer hair cells, Hearing Res. 54 (1991), 101–117.
- CD Geisler and C. Sang, A cochlear model using feed-forward outer hair cell forces, Hearing Res. 86 (1995), 132–146.
- J. Howard and A. J. Hudspeth, Compliance of the Hair Bundle Associated with Gating of Mechanoelectrical Transduction Channels in the Bullfrog’s Saccular Hair Cell, Neuron 1 (1988), 189–199.
- A. J. Hudspeth, Integrating the active process of hair cells with cochlear function, Nature Reviews 15 (2014), 600–614.
- Lydia Peres Hari, Jacob Rubinstein, and Peter Sternberg, Reduced equations for the hydroelastic waves in the cochlea: the spring model, Quart. Appl. Math. 74 (2016), no. 4, 647–670. MR 3539027, DOI 10.1090/qam/1443
- Jacob Rubinstein and Peter Sternberg, Reduced equations for the hydroelastic waves in the cochlea: the membrane model, Pure Appl. Funct. Anal. 5 (2020), no. 2, 457–471. MR 4089024
- Y. Yoon, S. Puria, and CR Steele, A cochlear model using the time-averaged Lagrangian and the push-pull mechanism in the organ of Corti, J. Mech. Mater. Struct. 4 (2009), 977–986.
- Y. Yoon, S. Puria, and CR Steele, Feed-forward and Feed-backward amplification model from cochlear cytoarchitecture: An interspecies comparison, Biophysics J. 100 (2011), 1–10.
- J. Zheng, W. Shen, DZ He, KB Long, LB Madison and P. Dallos, Prestin is the motor protein of cohlear outer hair cells, Nature 405 (2000), 149–155.
References
- J. Ashmore et al., The remarkable cochlear amplifier, Hearing Res. 266 (2006), 1–17.
- J. Berger and J. Rubinstein, Anatomic set of mechanical models for the organ of Corti, preprint.
- P. Dallos, The active cochlea, J. Neuroscience 12 (1992), 4575–4585.
- CD Geisler, A cochlear model using feedback from motile outer hair cells, Hearing Res. 54 (1991), 101–117.
- CD Geisler and C. Sang, A cochlear model using feed-forward outer hair cell forces, Hearing Res. 86 (1995), 132–146.
- J. Howard and A. J. Hudspeth, Compliance of the Hair Bundle Associated with Gating of Mechanoelectrical Transduction Channels in the Bullfrog’s Saccular Hair Cell, Neuron 1 (1988), 189–199.
- A. J. Hudspeth, Integrating the active process of hair cells with cochlear function, Nature Reviews 15 (2014), 600–614.
- Lydia Peres Hari, Jacob Rubinstein, and Peter Sternberg, Reduced equations for the hydroelastic waves in the cochlea: the spring model, Quart. Appl. Math. 74 (2016), no. 4, 647–670. MR 3539027, DOI 10.1090/qam/1443
- Jacob Rubinstein and Peter Sternberg, Reduced equations for the hydroelastic waves in the cochlea: the membrane model, Pure Appl. Funct. Anal. 5 (2020), no. 2, 457–471. MR 4089024
- Y. Yoon, S. Puria, and CR Steele, A cochlear model using the time-averaged Lagrangian and the push-pull mechanism in the organ of Corti, J. Mech. Mater. Struct. 4 (2009), 977–986.
- Y. Yoon, S. Puria, and CR Steele, Feed-forward and Feed-backward amplification model from cochlear cytoarchitecture: An interspecies comparison, Biophysics J. 100 (2011), 1–10.
- J. Zheng, W. Shen, DZ He, KB Long, LB Madison and P. Dallos, Prestin is the motor protein of cohlear outer hair cells, Nature 405 (2000), 149–155.
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Additional Information
Jacob Rubinstein
Affiliation:
Department of Mathematics, Technion, I.I.T., 32000 Haifa, Israel
MR Author ID:
204416
Email:
koby@technion.ac.il
Peter Sternberg
Affiliation:
Department of Mathematics, Indiana University, Bloomington, Indiana 47405
MR Author ID:
167150
Email:
sternber@indiana.edu
Received by editor(s):
August 7, 2020
Received by editor(s) in revised form:
August 17, 2020
Published electronically:
October 14, 2020
Additional Notes:
The first author acknowledges the support from a grant supplied by the Israel Science Foundation.
The second author acknowledges the support from a Simons Collaboration grant 585520.
Article copyright:
© Copyright 2020
Brown University