Finite-time blow-up in a degenerate chemotaxis system with flux limitation

By Nicola Bellomo and Michael Winkler

Abstract

This paper is concerned with radially symmetric solutions of the parabolic-elliptic version of the Keller-Segel system with flux limitation, as given by

under the initial condition and no-flux boundary conditions in a ball , where and . A previous result of the authors [Comm. Partial Differential Equations 42 (2017), 436–473] has asserted global existence of bounded classical solutions for arbitrary positive radial initial data when either and , or and .

This present paper shows that these conditions are essentially optimal: Indeed, it is shown that if the taxis coefficient satisfies , then for any choice of

there exist positive initial data satisfying which are such that for some , () possesses a uniquely determined classical solution in blowing up at time in the sense that .

This result is derived by means of a comparison argument applied to the doubly degenerate scalar parabolic equation satisfied by the mass accumulation function associated with ().

1. Introduction

Flux-limited Keller-Segel systems

This paper presents a continuation of the analytical study Reference 8 of a flux-limited chemotaxis model recently derived as a development of the classical pattern formation model proposed by Keller and Segel (Reference 30) to model collective behavior of populations mediated by a chemoattractant. In a general form, this model describes the spatio-temporal evolution of the cell density and the chemoattractant concentration by means of the parabolic system

where and denote the respective diffusivity terms, represents the chemotactic sensitivity, and and account for mechanisms of proliferation, degradation, and possibly also interaction. In comparison to the original Keller-Segel system, besides including cell diffusivity inhibited at small densities and hence supporting finite propagation speeds, the main innovative aspect in Equation 1.1 apparently consists in the choice of limited-diffusive and cross-diffusive fluxes in the first equation by a dynamics which is sensitive to gradients.

The heuristic interpretation of the flux-limited nonlinearity in the diffusion terms is induced by the ability that living entities, in general self-propelled particles, show to perceive not only local density, but also gradients. This particular feature characterizes cells (Reference 41), but also human crowds (Reference 4,Reference 5). This special sensitivity can be introduced in the modeling at the microscopic scale, namely at the scale of cells, thus leading to the description of multicellular systems by equations obtained by suitable generalizations of the approach of the mathematical kinetic theory.

The state of the system is, in this approach, defined by a probability one particle distribution function over the microscopic state, which includes position and velocity, of the interacting entities, while cell-cell interactions are modeled by theoretical tools of stochastic game theory. Interactions are nonlinearly additive, generally nonlocal, and can include the aforementioned sensitivity ability. Once the kinetic-type model has been derived, the study developed in Reference 6 has shown that the particular mathematical structure in Equation 1.1 can be derived by asymptotic limits and time-space scaling. The development of these asymptotic limits is inspired by the classical Hilbert method known in the kinetic theory of classical particles (Reference 18).

The interest in the qualitative analysis of solutions to phenomenologically derived models for taxis processes (Reference 25) has generated a variety of interesting analytical results reviewed in Reference 26 and more recently in Reference 7. Within this general framework the role of nonlinear diffusion and, specifically, of flux-limited diffusion, has posed some challenging problems at various levels. Experimental activity toward a thorough understanding of this specific type of mechanism is deeply analyzed in Reference 41, while so far the mathematical literature apparently has concentrated on studying such flux-limited diffusion processes either without any interaction with further processes, or with comparatively mild couplings such as to zero-order source terms e.g. of Fisher-KPP type; corresponding results on existence and on propagation properties can be found in Reference 1, Reference 2, Reference 3, Reference 14, Reference 15, and Reference 16, for instance (cf. also the survey Reference 13).

Blow-up in semilinear and quasilinear chemotaxis systems

The goal of the present work is to clarify to what extent the introduction of such flux limitations may suppress phenomena of blow-up, as known to constitute one of the most striking characteristic features of the classical Keller-Segel system

and also of several among its derivatives. Indeed, the Neumann initial-boundary value problem for Equation 1.2 is known to possess solutions blowing up in finite time with respect to the spatial norm of when either the spatial dimension satisfies (Reference 45), or when and the initially present—and thereafter conserved—total mass of cells is suitably large (Reference 24, Reference 34). On the other hand, in the case appropriately small values of warrant global existence of bounded solutions Reference 36, whereas if , then global bounded solutions exist under alternative smallness conditions involving the norms of in (Reference 17, Reference 42). In the associated spatially one-dimensional problem, global bounded solutions exist for all reasonably regular initial data, thus reflecting absence of any blow-up phenomenon in this case (Reference 38).

The knowledge on corresponding features of quasilinear relatives of Equation 1.2 seems most developed for models involving density-dependent variants in the diffusivity and the chemotactic sensitivity. For instance, if and are smooth positive functions on , then the Neumann problem for

possesses some unbounded solutions whenever for all and some and (Reference 44). Beyond this, refined studies have given additional conditions on and under which this singularity formation must occur within finite time, and have moreover identified some particular cases of essentially algebraic behavior of both and in which these explosions must occur in infinite time only (Reference 20, Reference 21, Reference 22; see also Reference 19 for a related example on finite-time blow-up). The optimality of the above growth condition is indicated by a result in Reference 40 and Reference 28 asserting global existence of bounded solutions in the case when for with some and , provided that decays at most algebraically as (cf. e.g. Reference 32, Reference 27, Reference 46, and Reference 39 for some among the numerous precedents in this direction).

Besides this, a considerable literature has identified several additional mechanisms as capable of suppressing explosions in Keller-Segel-type systems. These may consist of certain saturation effects in the signal production process at large densities (Reference 33, Reference 11) or in further dissipation due to superlinear death effects in frameworks of logistic-type cell proliferation (Reference 37, Reference 43), for instance. A recent deep result has revealed that even the mere inclusion of transport effects by appropriately constructed incompressible vector fields can prevent blow-up in otherwise essentially unchanged Keller-Segel systems in spatially two- and three-dimensional settings (Reference 31).

As compared to this, the literature on variants of Equation 1.2 involving modifications of the dependence of fluxes on gradients seems quite thin. Moreover, the few results available in this direction mainly seem to concentrate on modifications in the cross-diffusive term, essentially guided by the underlying idea to rule out blow-up by suitable regularization of the taxis term in Equation 1.2, as apparently justified in appropriate biological contexts (see the discussion in Reference 25 as well as the analytical findings reported there). In particular, we are not aware of any result detecting an explosion in any such context; this may reflect the evident challenges connected to rigorously proving the occurrence of blow-up in such complex chemotaxis systems.

Main results: Detecting blow-up under optimal conditions

The present work will reveal that actually also the introduction of flux limitations need not necessarily suppress phenomena of chemotactic collapse in the sense of blow-up. In order to make this manifest in a particular setting, let us concentrate on the case when in Equation 1.1 we have and as well as , and in order to simplify our analysis let us moreover pass to a parabolic-elliptic simplification thereof, thus focusing on a frequently considered limit case of fast signal diffusion (Reference 29). Here we note that e.g. in the previously discussed situations of Equation 1.2 and Equation 1.3, up to few exceptions (Reference 10) such parabolic-elliptic variants are known to essentially share the same properties as the respective fully parabolic model with regard to the occurrence of blow-up (Reference 35, Reference 9, Reference 12, Reference 23).

We shall thus subsequently be concerned with the initial-boundary value problem

in a ball , , where and the initial data are such that

and where

denotes the spatial average of the latter.

In fact, it has been shown in Reference 8 that this problem is well-posed, locally in time, in the following sense.

Theorem A.

Let , and with some , and suppose that complies with Equation 1.5. Then there exist and a uniquely determined pair of positive radially symmetric functions and which solve Equation 1.4 classically in , and which are such that

Now in order to formulate our results and put them in perspective adequately, let us moreover recall the following statement on global existence and boundedness in certain subcritical cases which has been achieved in Reference 8.

Theorem B.

Let with some , and assume that satisfies Equation 1.5, and that either

or

where in the case we have set

Then the problem Equation 1.4 possesses a unique global classical solution which is radially symmetric and such that for some we have

It is the purpose of the present work to complement the above result on global existence by showing that in both cases and , the conditions Equation 1.8 and Equation 1.9 are by no means artificial and of purely technical nature, but that in fact they are essentially optimal in the sense that if appropriate reverse inequalities hold, then finite-time blow-up may occur. To be more precise, the main results of this paper can be formulated as follows.

Theorem 1.1.

Let and with some , and suppose that

and that

where is as in Equation 1.10. Then there exists a nondecreasing function fulfilling and , which is such that whenever satisfies Equation 1.5 as well as

the solution of Equation 1.4 blows up in finite time in the sense that in Theorem A we have and

Indeed the set of all initial data leading to explosions in Equation 1.4 is considerably large in that it firstly contains an open subset with respect to the norm in , and that it secondly possesses some density property within the set of all initial data admissible in the sense of Equation 1.5.

Proposition 1.2.

Let , , , and .

(i) Let satisfy Equation 1.13. Then there exists a radially symmetric positive which is such that on and , and for which it is possible to choose with the property that whenever satisfies Equation 1.5 as well as , the corresponding solution of Equation 1.4 blows up in finite time.

(ii) Given any fulfilling Equation 1.5, one can find functions , which satisfy Equation 1.5 and in as for all , and which are such that for all the solution of Equation 1.4 emanating from blows up in finite time.

In comparison to the classical Keller-Segel system Equation 1.2, these results in particular mean that when , the possible occurrence of blow-up does not go along with a critical mass phenomenon, but that there rather exists a critical sensitivity parameter, namely , which distinguishes between existence and nonexistence of blow-up solutions. On the other hand, if , then for any , beyond this there exists a critical mass phenomenon, in quite the same flavor as present in Equation 1.2 when .

Plan of the paper

Due to the apparent lack of an adequate global dissipative structure, a blow-up analysis for Equation 1.4 cannot be built on the investigation of any energy functional, as possible in both the original Keller-Segel system Equation 1.2 and its quasilinear variant Equation 1.3 (Reference 45, Reference 34, Reference 20). Apart from this, any reasoning in this direction needs to adequately cope with the circumstance that as compared to Equation 1.2, in Equation 1.4 the cross-diffusive flux is considerably inhibited wherever is large, which seems to prevent access to blow-up arguments based on tracking the evolution of weighted norms of such as e.g. the moment-like functionals considered in Reference 35.

That blow-up may occur despite this strong limitation of cross-diffusive flux will rather be shown by a comparison argument. Indeed, it can readily be verified (Lemma 2.1) that given a radial solution of Equation 1.4 in , the mass accumulation function , as defined in a standard manner by introducing

satisfies a scalar parabolic equation which is doubly degenerate, both in space as well as with respect to the variable , but after all allows for an appropriate comparison principle for certain generalized sub- and supersolutions (Lemma 5.1).

Accordingly, at the core of our analysis will be the construction of suitable subsolutions to the respective problem; in fact, we shall find such subsolutions which undergo a finite-time gradient blow-up at the origin in the sense that for some we have as , implying blow-up of before or at time whenever lies above . These subsolutions will have a composite structure to be described in Lemma 3.2, matching a nonlinear and essentially parabola-like behavior in a small ball around the origin to an affine linear behavior in a corresponding outer annulus, the latter increasing so as to coincide with the whole domain at the blow-up time of . The technical challenge, to be addressed in Section 3, will then consist of carefully adjusting the parameters in the definition of in such a manner that the resulting function in fact has the desired blow-up property, where the cases and will require partially different arguments (Lemma 3.11 and Lemma 3.12). The statement from Theorem 1.1 will thereafter result in Section 4.

2. A parabolic problem satisfied by the mass accumulation function

Throughout the rest of the paper, we fix and consider Equation 1.4 in the spatial domain , . Then following a standard procedure (Reference 29), given a radially symmetric solution of Equation 1.4 in for some , we consider the associated mass accumulation function given by

In order to describe a basic property of naturally inherited from through Equation 1.4, let us furthermore introduce the parabolic operator formally given by

We note here that for , the above expression is indeed well-defined for all and a.e.  if, for instance, is such that throughout and for all .

Now the function in Equation 2.1, which clearly complies with these requirements due to smoothness and positivity of , in fact solves an appropriate initial-boundary value problem associated with :

Lemma 2.1.

Let and , and suppose that is a positive radially symmetric classical solution of Equation 1.4 in for some and some nonnegative radially symmetric . Then the function defined in Equation 2.1 satisfies

where and where denotes the -dimensional measure of the unit sphere in .

Proof.

Omitting the arguments and in expressions like and , upon an integration in the radial version of the first equation in Equation 1.4 we obtain

for and . Here in order to replace , we integrate the second equation in Equation 1.4, that is, the identity , to see that

Furthermore Equation 2.1 can be used to derive

to infer from Equation 2.4 that

for and . This proves the parabolic equation in Equation 2.3, whereas the statements therein concerning boundary and initial conditions can easily be checked using Equation 2.1 and the mass conservation property for .

3. Construction of subsolutions for Equation 2.3

The goal of this section is to construct subsolutions for the parabolic operator introduced in Equation 2.2 which after some finite time exhibit a phenomenon of gradient blow-up in the strong sense that

Since by means of a suitable comparison principle (cf. Lemma 5.1 in the appendix) we will be able to assert that in , this will entail a similar conclusion for and hence prove that cannot exist as a bounded solution in .

Our comparison functions will be chosen from a family of explicitly given functions , the general form of which will be described in Section 3.1. These functions will exhibit a two-component coarse structure, as reflected in substantially different definitions in a temporally shrinking inner region near the spatial origin, and a corresponding outer part. According to a further fine structure in the inner subdomain, our verification of the desired subsolution properties will be split into three parts, to be detailed in Section 3.2, Section 3.3, and Section 3.4, respectively.

3.1. Constructing a family of candidates

Our construction will involve several parameters. The first of these is a number which eventually, as we shall see later, can be chosen arbitrarily when (see Lemma 3.12), but needs to be fixed appropriately close to in the case , depending on the size of the mass (Lemma 3.11). Leaving this final choice open at this point, given any we abbreviate

and introduce

It can then easily be verified that belongs to with

and

whence in particular for all .

Let us furthermore introduce a collection of time-dependent parameter functions which play a crucial role throughout the rest of the paper.

Lemma 3.1.

Let , , , , , and be such that and for all , and that moreover

where and are as in Equation 3.1. Then

as well as

and

for , with

are all well-defined, and we have

and

for all .

Proof.

Firstly, thanks to Equation 3.5 we have

which in particular guarantees that the denominators in Equation 3.6, Equation 3.7, and Equation 3.8 are all positive and hence all these functions are well-defined throughout . Moreover, differentiating in Equation 3.6 we can compute

which establishes Equation 3.10. Similarly, differentiation in Equation 3.7 readily yields Equation 3.11.

With these definitions, we can now specify the basic structure of our comparison functions to be used in the sequel. Here a second parameter enters, to be chosen suitably large finally, as well as a parameter function depending on time. In combination, these two ingredients determine a line in the -plane which will separate an inner from an outer region and thereby imply a composite structure of as follows.

Lemma 3.2.

Let , , , and , and suppose that and that is such that Equation 3.5 holds as well as and for all . Let

where

with as in Equation 3.2 and as in Equation 3.6, and where

with and taken from Equation 3.7 and Equation 3.8.

Then is well-defined and continuously differentiable in and in addition satisfies for all as well as

Proof.

We first note that for each , both intervals and in Equation 3.12 are not empty due to our assumptions that and , and that furthermore both statements in Equation 3.15 are direct consequences of Equation 3.8 and the fact that according to Equation 3.2.

To establish the claimed regularity properties of , in view of the above observation that we only need to make sure that , , and are continuous along the line where , which amounts to showing that

and

as well as

for all .

To derive Equation 3.16, we use Equation 3.2 to see that

which due to Equation 3.8 means that indeed

Next, from Equation 3.7 and Equation 3.6 it immediately follows that

which establishes Equation 3.17.

Finally, in verifying Equation 3.18 we make use of Equation 3.16 and Equation 3.17 as well as Equation 3.6, Equation 3.7, Equation 3.8, Equation 3.10, and Equation 3.11 to see that

for all .

Since it can be checked in a straightforward manner that herein we have

this shows Equation 3.18 and thereby completes the proof.

3.2. Subsolution properties: Outer region

Let us first make sure that if the function entering the above definition of is suitably small and satisfies an appropriate differential inequality, then becomes a subsolution in the corresponding outer region addressed in Equation 3.12.

Lemma 3.3.

Let , and be such that and

with and given by Equation 3.1. Then if for some , is positive and nonincreasing and such that

the function defined in Equation 3.14 satisfies

with given by Equation 2.2.

Proof.

Again using that for all by Equation 3.8, we have

for all and . Hence, recalling Equation 3.11 we obtain

for all and , where is as in Equation 3.9 for such . In order to compensate the positive contribution of this term to by a suitably negative impact of the rightmost term

in Equation 2.2, we use Equation 3.22 and Equation 3.7 to rewrite

for and . As

by Equation 3.19, this in particular implies that

and hence

Since moreover for all due to the fact that , we can thus estimate the denominator in Equation 3.24 in the considered outer region according to

for all and .

Using Equation 3.27 and Equation 3.25 and that

for and , we thereby find that

for all and , with as defined in Equation 3.9 and

Since evidently , combining this with Equation 3.26 and Equation 3.23 shows that

for all and , because for all . In view of the definition of , Equation 3.20 warrants that herein

so that Equation 3.21 results from Equation 3.28.

3.3. Subsolution properties: Inner region

We proceed to study under which assumptions on the parameters the function defines a subsolution in the corresponding inner domain. To prepare our analysis, let us first compute the action of the operator on in the respective region as follows.

Lemma 3.4.

Let , , , and , and suppose that is positive and satisfies Equation 3.5 as well as for all . Then the function defined in Equation 3.13 has the property that

for all and , where , is as in Equation 2.2, and

and

for and .

Proof.

Since and , we can compute

as well as

for all and .

Therefore,

and

for any such and .

Finally, by definition Equation 2.2 of , Equation 3.32Equation 3.34 prove Equation 3.29.

In further examining Equation 3.29, it will be convenient to know that the factor appearing in Equation 3.13 is nonincreasing with time, meaning that the first summand on the right-hand side in Equation 3.29 will be nonpositive. It is the objective of the following lemma to assert that this can indeed be achieved by choosing the function to be nonincreasing and appropriately small throughout .

Lemma 3.5.

Let , and be such that , and suppose that satisfies

Then if and is a positive and nonincreasing function fulfilling , for the function in Equation 3.6 we have

In particular,

Proof.

We recall that by Equation 3.10, with given by Equation 3.9 we have

Here since our assumption Equation 3.35 implies that , by monotonicity of we obtain that

whereas the inequality ensures that

Again using that , from Equation 3.38 we thus conclude that Equation 3.36 holds, whereupon Equation 3.37 follows upon taking in Equation 3.6.

3.4. Subsolution properties: Very inner region

Now in the part very near the origin where and hence , the expression in Equation 3.29, originating from the chemotactic term in Equation 1.4, need not be positive due to Equation 3.2 and the linear growth of the minuend in the numerator in Equation 3.31. Fortunately, it turns out that the respective unfavorable effect of this to in Equation 3.29 can be overbalanced by a suitable contribution of , which in fact is negative in this region due to the convexity of on . Under an additional smallness assumption on , we can indeed achieve the following.

Lemma 3.6.

Let , and be such that and

as well as

Suppose that and that is a positive and nonincreasing function satisfying

Then the function defined in Equation 3.13 has the property that

Proof.

Writing for and , in Equation 3.29 we can estimate the taxis term from above according to

We next recall that since whenever , and hence and , we have

because throughout . Now since thanks to the convexity of on , in Equation 3.30 we therefore find that

As and hence , due to Equation 3.43 we thereby obtain from Equation 3.29, applying Lemma 3.5 on the basis of Equation 3.39, that

for all and . Here, using that implies that , and that the restriction Equation 3.40 on ensures that

we see that

As a consequence of Equation 3.41, the claim therefore results from Equation 3.44.

3.5. Subsolution properties: Intermediate region

The crucial part of our analysis will be concerned with the remaining intermediate region, that is, the outer part of the inner domain where . Here the term in Equation 3.29, reflecting the diffusion mechanism in Equation 1.4 and thus inhibiting the tendency toward blow-up, can be estimated from above as follows.

Lemma 3.7.

Let , and , and suppose that is positive and such that Equation 3.5 holds as well as for all . Then writing , for the function introduced in Equation 3.30 we have

Proof.

Since and hence by Equation 3.4, we have , so that we may use the trivial estimate

to infer that

holds for any such and , as claimed.

Our goal will accordingly consist of controlling the term in Equation 3.29 from above by a suitably negative quantity. As a first step toward this, we shall make sure that in the root appearing in the denominator of Equation 3.31, the second summand essentially dominates the first upon appropriate choices of the parameters.

Lemma 3.8.

Let with , and be such that and

Suppose that for some , is positive and nonincreasing and such that . Then writing for and , we have

for all and .

Proof.

Since and Equation 3.46 holds, we know from Lemma 3.5 that for all with given by Equation 3.37. Moreover, the fact that is increasing on allows us to estimate for all and , because for any such and we have . Hence,

for all and .

As , we may use the restriction implied by the inequality to estimate

Therefore, Equation 3.47 is a consequence of Equation 3.48.

In order to prepare an estimate for the numerator in Equation 3.31 from below, let us state and prove the following elementary calculus lemma.

Lemma 3.9.

For , let and be as defined in Equation 3.1, and let

Then if the numbers and satisfy

we have

Proof.

Differentiation in Equation 3.49 yields

from which we obtain that

where and are given by

Here by Equation 3.1, we recall that in computing

Hence,

implying that . Therefore, Equation 3.52 entails that

where

Since Equation 3.50 ensures that and thus

the inequality Equation 3.53 thus yields Equation 3.51.

On the basis of the above lemma, we can indeed achieve that in the numerator in Equation 3.31 the positive summand prevails.

Lemma 3.10.

Let , and such that and

as well as

with and as in Equation 1.6 and Equation 3.37, respectively. Furthermore, let and be positive and such that

Then writing , we have

Proof.

With taken from Lemma 3.9, we first observe that

for all and . Here thanks to Equation 3.54 and Equation 3.56 we may apply Lemma 3.9, which combined with Equation 3.37 shows that

for all and .

In light of Equation 3.55, the conclusion Equation 3.57 is therefore a consequence of Equation 3.58.

With the above preparations at hand, we can proceed to show that under the assumptions of Theorem 1.1, if is a suitably small nonincreasing function satisfying an appropriate differential inequality, then indeed becomes a subsolution of Equation 2.3 in the intermediate region where .

We shall first demonstrate this in the spatially one-dimensional case, in which the role of the number in Equation 1.10 will become clear through the following lemma.

Lemma 3.11.

Let , and . Then there exist , , , and such that , and such that whenever and is a positive and nonincreasing function fulfilling Equation 3.5 as well as

then for as in Equation 3.13 we have

Proof.

As , we have , whence it is possible to fix sufficiently close to such that

This in turn allows us to choose some such that

is positive. We thereafter pick such that with and as in Equation 3.1 we have

and

Finally, we take conveniently small fulfilling and

as well as

with as in Equation 3.37, and let

Then given any and a positive nonincreasing satisfying Equation 3.59, from Lemma 3.5 in conjunction with Equation 3.62 we know that on , so that Equation 3.29 yields

for all and , with and and as given by Equation 3.30 and Equation 3.31.

Here, Lemma 3.7 says that

and in order to compensate this positive contribution in Equation 3.67 appropriately, we first invoke Lemma 3.10, which ensures that thanks to Equation 3.64 and Equation 3.65 we have

In particular, this implies that the expression on the left-hand side herein is nonnegative, so that we can estimate

Since Equation 3.62 and Equation 3.64 allow for an application of Lemma 3.8, we moreover know that

because of Equation 3.63. Combining this with Equation 3.70 shows that in the denominator in the definition Equation 3.31 of we have

for all and . So that by means of Equation 3.69 we can estimate

Together with Equation 3.66 and Equation 3.68, in view of the definition Equation 3.61 of this implies that

Once more using that in the considered region we have , due to our choice of we infer that

because of Equation 3.59, whereby the proof is completed.

In the case , we follow the same basic strategy as above, but numerous adaptations are necessary due to the fact that in this case the more involved, and more degenerate, structure of and in Equation 3.29 allows for choosing actually any positive value of the mass whenever .

Lemma 3.12.

Let , and , and let be arbitrary. Then there exist , , and such that , and such that if and is positive and nonincreasing such that

then the function defined in Equation 3.14 satisfies

Proof.

We let and as in Equation 3.1, take any fulfilling

and use that to pick suitably small such that

It is the possible to fix such that and

such that with as in Equation 3.37 we have

and such that

where we note that in achieving the latter we make use of our assumption that . We finally let

and suppose that and that is positive and nonincreasing and such that Equation 3.71 holds.

Then Equation 3.73 and Equation 3.75 warrant that Lemma 3.5 applies so as to yield that on , and that hence by Equation 3.29,

for all and , where again , and where and are as defined in Equation 3.30 and Equation 3.31, respectively. Now thanks to Equation 3.75 and Equation 3.76, Lemma 3.10 shows that

whereas Equation 3.75 allows for invoking Lemma 3.8 to infer from Equation 3.77 that

By means of Equation 3.80, Equation 3.81, and the fact that , we can thus estimate according to

for all and . Since on the other hand

due to Lemma 3.10, we therefore conclude from Equation 3.79 that

for all and . We finally observe that whenever , and that hence by Equation 3.78,

for all and , so that Equation 3.71 and Equation 3.82 guarantee that indeed the claimed inequality Equation 3.72 holds.

4. Blow-up. Proof of Theorem 1.1

Now our main result on blow-up of solutions to the original problem can be derived by a combination of Lemma 3.3 with Lemma 3.6 as well Lemma 3.11 and Lemma 3.12 in the cases and , respectively, along with a straightforward comparison argument.

Proof of Theorem 1.1.

Thanks to our assumptions Equation 1.12 and Equation 1.13, depending on whether or we may invoke either Lemma 3.11 or Lemma 3.12 to obtain , and with the respective properties listed there. We then fix such that Equation 3.19, Equation 3.39, and Equation 3.40 hold, and thereafter we take some satisfying

as well as

In view of Lemma 3.3, Lemma 3.6, Lemma 3.11, and Lemma 3.12, these choices ensure that if we let denote the solution of

extended up to its extinction time , that is, if we define

with

then the functions and given by Equation 3.14 and Equation 3.13 are well-defined and satisfy

as well as

Here in employing Lemma 3.3 we make use of Equation 4.1, whereas in applying Lemma 3.6 we note that for all due to Equation 4.2 and the fact that for all . According to Equation 4.6 and Equation 4.7, Lemma 3.2 asserts that

defines a function which satisfies

as well as

Therefore, if satisfies Equation 1.5 and is such that

then the solution of Equation 2.3 defined through Equation 2.1 satisfies

and furthermore it is clear that

where . In order to assert applicability of the comparison principle from Lemma 5.1 below, we abbreviate and let

for , so that with

and

for all , as well as

for all .

Therefore, we can estimate

and

Since the inequalities Equation 4.10, Equation 4.11, and Equation 4.12 warrant the validity of the hypotheses Equation 5.1, Equation 5.3, and Equation 5.2 of Lemma 5.1, as a consequence of the latter we obtain that

As for all , by the mean value theorem this implies that for each we can find some with the property that

Recalling that for all and , we thereby infer that

In view of the fact that as , and that hence as according to Equation 3.6, this entails that we necessarily must have , so that Equation 1.15 becomes a consequence of the extensibility criterion Equation 1.7.

Proof of Proposition 1.2.

As a preparation for both parts of the proof, let us fix a nonincreasing such that in , in , and , and note that then throughout .

(i) In order to construct for fulfilling Equation 1.13, given any such we pick numbers and such that and such that if we moreover have , and thereafter we choose small enough satisfying

where we rely on Theorem 1.1 in observing that the expression on the right-hand side herein indeed is finite. Then with and ,

evidently defines a positive radial function satisfying on , and moreover our selection of warrants that

because . Apart from that, since we similarly see that

so that in the case we can use our definition of to estimate

whereas if , then

In view of Equation 4.13, we thus conclude that

while evidently

We now let and suppose that satisfies Equation 1.5 and is such that . Then from Equation 4.14 we infer that since ,

and Equation 4.15 guarantees that

since and since is nondecreasing with by Theorem 1.1.

Therefore, for all , so that Theorem 1.1 asserts that indeed for any such the corresponding solution of Equation 1.4 must blow up.

(ii) To verify the claimed density property, we fix an arbitrary fulfilling Equation 1.13, and choose any such that as . Then taking as above, for each the function defined by

with , evidently satisfies Equation 1.5, and for all we have

because as for any such . In view of Theorem 1.1, for completing the proof it is thus sufficient to make sure that if we fix large enough fulfilling

then

In fact, for any such we may use that and proceed in a way quite similar to that in part (i) to estimate

whence by Equation 4.16,

and

for all . As moreover

due to the monotonicity of and the fact that , we thus infer that Equation 4.17 indeed holds.

5. Appendix: A comparison lemma

An ingredient essential to our argument is the following variant of the parabolic comparison principle. Since we could not find an appropriate reference precisely covering the present situation, especially involving the present particular type of degenerate diffusion and nonsmooth comparison functions, we include a proof for completeness.

Lemma 5.1.

Let , and be such that

that for all and there exists fulfilling

with and , and such that for any we have

Suppose that and are two functions which belong to and satisfy

as well as

If moreover

for all and a.e. , further

as well as

then

Proof.

We fix an arbitrary and then obtain from Equation 5.4 and the assumed regularity properties of and that there exists such that

For , we then let with as in Equation 5.2, define

and claim that

To verify this, supposing for contradiction that Equation 5.12 is false, from Equation 5.7 and Equation 5.8 we would infer the existence of and such that

in particular implying that

and

Moreover, using Equation 5.15 we obtain that , so that we can find a null set such that exists for all and

according to Equation 5.15, where for later use we note that enlarging if necessary we can furthermore achieve that both inequalities in Equation 5.6 are valid at for all . As attains its maximum at by Equation 5.13, the identity Equation 5.16 necessarily requires that there exists such that as and

for otherwise Equation 5.16 would imply that for all with some , which would clearly contradict Equation 5.13.

Now differentiating Equation 5.11, in view of Equation 5.6 and our choice of we see that

so that from Equation 5.17 we infer that

Here by the mean value theorem we have

with

and

for . Since as , by continuity of and in , by continuity and positivity of and in , and by local boundedness of in asserted by Equation 5.5, we can find such that

for all .

As a consequence of this and Equation 5.3, there exists fulfilling

Moreover, combining Equation 5.10 with Equation 5.2, by definition of we obtain that

Collecting Equation 5.19, Equation 5.20, and Equation 5.21 in Equation 5.18 we can further estimate

for all .

Thanks to the fact that both and belong to , we may take here to see that

Now observing that by Equation 5.13, and that by Equation 5.15, as a consequence of Equation 5.14 we infer that

This absurd conclusion shows that actually Equation 5.12 indeed holds, so that on letting and then we end up with Equation 5.9.

Acknowledgement

The authors warmly thank the anonymous referee for numerous fruitful remarks which have led to a substantial improvement of this paper.

Mathematical Fragments

Equation (1.1)
Equation (1.2)
Equation (1.3)
Equation (1.4)
Equation (1.5)
Equation (1.6)
Theorem A.

Let , and with some , and suppose that complies with Equation 1.5. Then there exist and a uniquely determined pair of positive radially symmetric functions and which solve Equation 1.4 classically in , and which are such that

Theorem B.

Let with some , and assume that satisfies Equation 1.5, and that either

or

where in the case we have set

Then the problem Equation 1.4 possesses a unique global classical solution which is radially symmetric and such that for some we have

Theorem 1.1.

Let and with some , and suppose that

and that

where is as in Equation 1.10. Then there exists a nondecreasing function fulfilling and , which is such that whenever satisfies Equation 1.5 as well as

the solution of Equation 1.4 blows up in finite time in the sense that in Theorem A we have and

Proposition 1.2.

Let , , , and .

(i) Let satisfy Equation 1.13. Then there exists a radially symmetric positive which is such that on and , and for which it is possible to choose with the property that whenever satisfies Equation 1.5 as well as , the corresponding solution of Equation 1.4 blows up in finite time.

(ii) Given any fulfilling Equation 1.5, one can find functions , which satisfy Equation 1.5 and in as for all , and which are such that for all the solution of Equation 1.4 emanating from blows up in finite time.

Equation (2.1)
Equation (2.2)
Lemma 2.1.

Let and , and suppose that is a positive radially symmetric classical solution of Equation 1.4 in for some and some nonnegative radially symmetric . Then the function defined in Equation 2.1 satisfies

where and where denotes the -dimensional measure of the unit sphere in .

Equation (2.4)
Equation (3.1)
Equation (3.2)
Equation (3.4)
Lemma 3.1.

Let , , , , , and be such that and for all , and that moreover

where and are as in Equation 3.1. Then

as well as

and

for , with

are all well-defined, and we have

and

for all .

Lemma 3.2.

Let , , , and , and suppose that and that is such that Equation 3.5 holds as well as and for all . Let

where

with as in Equation 3.2 and as in Equation 3.6, and where

with and taken from Equation 3.7 and Equation 3.8.

Then is well-defined and continuously differentiable in and in addition satisfies for all as well as

Equation (3.16)
Equation (3.17)
Equation (3.18)
Lemma 3.3.

Let , and be such that and

with and given by Equation 3.1. Then if for some , is positive and nonincreasing and such that

the function defined in Equation 3.14 satisfies

with given by Equation 2.2.

Equation (3.22)
Equation (3.23)
Equation (3.24)
Equation (3.25)
Equation (3.26)
Equation (3.27)
Equation (3.28)
Lemma 3.4.

Let , , , and , and suppose that is positive and satisfies Equation 3.5 as well as for all . Then the function defined in Equation 3.13 has the property that

for all and , where , is as in Equation 2.2, and

and

for and .

Equation (3.32)
Equation (3.34)
Lemma 3.5.

Let , and be such that , and suppose that satisfies

Then if and is a positive and nonincreasing function fulfilling , for the function in Equation 3.6 we have

In particular,

Equation (3.38)
Lemma 3.6.

Let , and be such that and

as well as

Suppose that and that is a positive and nonincreasing function satisfying

Then the function defined in Equation 3.13 has the property that

Equation (3.43)
Equation (3.44)
Lemma 3.7.

Let , and , and suppose that is positive and such that Equation 3.5 holds as well as for all . Then writing , for the function introduced in Equation 3.30 we have

Lemma 3.8.

Let with , and be such that and

Suppose that for some , is positive and nonincreasing and such that . Then writing for and , we have

for all and .

Equation (3.48)
Lemma 3.9.

For , let and be as defined in Equation 3.1, and let

Then if the numbers and satisfy

we have

Equation (3.52)
Equation (3.53)
Lemma 3.10.

Let , and such that and

as well as

with and as in Equation 1.6 and Equation 3.37, respectively. Furthermore, let and be positive and such that

Then writing , we have

Equation (3.58)
Lemma 3.11.

Let , and . Then there exist , , , and such that , and such that whenever and is a positive and nonincreasing function fulfilling Equation 3.5 as well as

then for as in Equation 3.13 we have

Equation (3.61)
Equation (3.62)
Equation (3.63)
Equation (3.64)
Equation (3.65)
Equation (3.66)
Equation (3.67)
Equation (3.68)
Equation (3.69)
Equation (3.70)
Lemma 3.12.

Let , and , and let be arbitrary. Then there exist , , and such that , and such that if and is positive and nonincreasing such that

then the function defined in Equation 3.14 satisfies

Equation (3.73)
Equation (3.75)
Equation (3.76)
Equation (3.77)
Equation (3.78)
Equation (3.79)
Equation (3.80)
Equation (3.81)
Equation (3.82)
Equation (4.1)
Equation (4.2)
Equation (4.6)
Equation (4.7)
Equation (4.10)
Equation (4.11)
Equation (4.12)
Equation (4.13)
Equation (4.14)
Equation (4.15)
Equation (4.16)
Equation (4.17)
Lemma 5.1.

Let , and be such that

that for all and there exists fulfilling

with and , and such that for any we have

Suppose that and are two functions which belong to and satisfy

as well as

If moreover

for all and a.e. , further

as well as

then

Equation (5.10)
Equation (5.11)
Equation (5.12)
Equation (5.13)
Equation (5.14)
Equation (5.15)
Equation (5.16)
Equation (5.17)
Equation (5.18)
Equation (5.19)
Equation (5.20)
Equation (5.21)

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Article Information

MSC 2010
Primary: 35B44 (Blow-up)
Secondary: 35K65 (Degenerate parabolic equations), 92C17 (Cell movement)
Keywords
  • Chemotaxis
  • flux limitation
  • blow-up
  • degenerate diffusion
Author Information
Nicola Bellomo
Department of Mathematics, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Address at time of publication: Politecnico of Torino, 10129 Torino, Italy
nicola.bellomo@polito.it
MathSciNet
Michael Winkler
Institut für Mathematik, Universität Paderborn, 33098 Paderborn, Germany
michael.winkler@math.uni-paderborn.de
MathSciNet
Additional Notes

The first author acknowledges partial support by the Italian Minister for University and Research, PRIN Project coordinated by M. Pulvirenti.

The second author acknowledges support by the Deutsche Forschungsgemeinschaft in the context of the project Analysis of chemotactic cross-diffusion in complex frameworks.

Journal Information
Transactions of the American Mathematical Society, Series B, Volume 4, Issue 2, ISSN 2330-0000, published by the American Mathematical Society, Providence, Rhode Island.
Publication History
This article was received on , revised on , and published on .
Copyright Information
Copyright 2017 by the authors under Creative Commons Attribution-Noncommercial 3.0 License (CC BY NC 3.0)
Article References
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  • DOI 10.1090/btran/17
  • MathSciNet Review: 3664719
  • Show rawAMSref \bib{3664719}{article}{ author={Bellomo, Nicola}, author={Winkler, Michael}, title={Finite-time blow-up in a degenerate chemotaxis system with flux limitation}, journal={Trans. Amer. Math. Soc. Ser. B}, volume={4}, number={2}, date={2017}, pages={31-67}, issn={2330-0000}, review={3664719}, doi={10.1090/btran/17}, }

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