Stability and instability of Liapunov-Schmidt and Hopf bifurcation for a free boundary problem arising in a tumor model

Authors:
Avner Friedman and Bei Hu

Journal:
Trans. Amer. Math. Soc. **360** (2008), 5291-5342

MSC (2000):
Primary 35R35, 35K55; Secondary 35Q80, 35C20, 92C37

DOI:
https://doi.org/10.1090/S0002-9947-08-04468-1

Published electronically:
February 27, 2008

MathSciNet review:
2415075

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Abstract | References | Similar Articles | Additional Information

Abstract: We consider a free boundary problem for a system of partial differential equations, which arises in a model of tumor growth. For any positive number $R$ there exists a radially symmetric stationary solution with free boundary $r=R$. The system depends on a positive parameter $\mu$, and for a sequence of values $\mu _2<\mu _3<\cdots$ there also exist branches of symmetric-breaking stationary solutions, parameterized by $\varepsilon$, $|\varepsilon |$ small, which bifurcate from these values. In particular, for $\mu =\mu (\varepsilon )$ near $\mu _2$ the free boundary has the form $r=R+\varepsilon Y_{2,0}(\theta )+O(\varepsilon ^2)$ where $Y_{2,0}$ is the spherical harmonic of mode $(2,0)$. It was recently proved by the authors that the stationary solution is asymptotically stable for any $0<\mu <\mu _*$, but linearly unstable if $\mu >\mu _*$, where $\mu _*=\mu _2$ if $R>\bar R$ and $\mu _*<\mu _2$ if $R<\bar R$; $\bar R\approx 0.62207$. In this paper we prove that for $R>\bar R$ each of the stationary solutions which bifurcates from $\mu =\mu _2$ is linearly stable if $\varepsilon >0$ and linearly unstable if $\varepsilon <0$. We also prove, for $R<\bar R$, that the point $\mu =\mu _*$ is a Hopf bifurcation, in the sense that the linearized time-dependent problem has a family of solutions which are asymptotically periodic in $t$.

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Additional Information

**Avner Friedman**

Affiliation:
Department of Mathematics, The Ohio State University, 231 West 18th Avenue, Columbus, Ohio 43210

Email:
afriedman@mbi.osu.edu

**Bei Hu**

Affiliation:
Department of Mathematics, University of Notre Dame, Notre Dame, Indiana 46556

Email:
b1hu@nd.edu

Keywords:
Free boundary problems,
stationary solution,
stability,
instability,
bifurcation,
symmetry-breaking,
tumor cell

Received by editor(s):
February 24, 2005

Received by editor(s) in revised form:
September 26, 2005, and September 6, 2006

Published electronically:
February 27, 2008

Article copyright:
© Copyright 2008
American Mathematical Society

The copyright for this article reverts to public domain 28 years after publication.